上海嘉定社区绝经后女性初潮年龄与成年后糖尿病及代谢综合征患病风险的相关性研究  

Association of age at menarche with the risks of diabetes mellitus and metabolic syndrome in adulthood in Shanghai Jiading community postmenopausal women

作　　者：胡春艳 林琳[1] 杜瑞[1] 吴雪妍 陈宇红[1] 陆洁莉[1] 毕宇芳[1] 王卫庆[1] 宁光[1] Hu Chunyan,Lin Lin,Du Rui,Wu Xueyan,Chen Yuhong,Lu Jieli,Bi Yufang,Wang Weiqing,Ning Guang(Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China)

机构地区：[1]上海交通大学医学院附属瑞金医院内分泌代谢病科、上海市内分泌代谢病研究所、上海市内分泌代谢病临床医学中心,200025

出　　处：《中华内分泌代谢杂志》2018年第10期814-820,共7页Chinese Journal of Endocrinology and Metabolism

摘　　要：目的 探讨上海社区绝经后女性初潮年龄与成年后糖尿病及代谢综合征（MS）患病风险的相关性。方法 采取整群抽样的方法，对上海嘉定地区10 375名40岁以上的常驻居民进行标准化问卷调查、体格检查、生化指标检测等。共4723名绝经后女性纳入研究，总人群按初潮年龄分组，比较各组MS及糖尿病的患病风险。结果 经多元校正之后，与初潮年龄15～18岁者相比，初潮年龄〈15岁的绝经后妇女糖尿病及MS的患病风险分别增加29％（95％CI1．03～1．61）和45％（95％CI1．20～1．76），且MS各组分中，低初潮年龄与高三酰甘油、低高密度脂蛋白胆固醇血症及腹型肥胖的风险增加有关。结论在上海嘉定社区绝经后女性中，初潮年龄〈15岁者糖尿病及MS的患病风险增加，且此相关性独立于成年时期的体重指数。Objective To investigate the association of age at menarche with the risks of diabetes and metabolic syndrome （MS） in adulthood in Shanghai community postmenopausal women. Methods A total of 10 375 residents over 40 years in Jiading, Shanghai were identified by a cluster sampling method. After taking standardized questionnaire surveys, physical examinations, and biochemical parameters testing, we gathered their lifestyle and medicine information. A total of 4 723 postmenopausal women were enrolled in the study. The population was divided into three groups according to age at menarche, and their risks of MS and diabetes in various groups were compared. Results After multivariate adjustment, postmenopausal women with a menarche age〈 15 years had a 29% increased risk of diabetes（95% CI 1.03-1.61 ） and a 45% increased risk of MS（ 95% CI 1.20-1.76） in adulthood, compared with those with menarcheal age at 15-18 years. Among the five components of MS, earlier age of menarche was associated with higher risks of hypertriglyceridemia, low high density lipoprotein-cholesterol, and central obesity. Conclusions In Shanghai Jiading community postmenopausal women, age at menarehe is associated with the risk of diabetes and MS, independent of the body mass index in adulthood.

关 键 词：初潮年龄 绝经状态 代谢综合征 糖尿病 体重指数 

分 类 号：R587.1[医药卫生—内分泌] R589[医药卫生—内科学]