冠心病患者替格瑞洛相关呼吸困难预测因素的分析  

Analysis of the predictors of ticagrelor-associated dyspnea in patients with coronary heart disease

作　　者：董加建 宋爽[1] 马心超 陈愿[1] 崔留义 赵子明 DONG Jiajian;SONG Shuang;MA Xinchao;CHEN Yuan;CUI Liuyi;ZHAO Ziming(Department of Cardiology,the Seventh People＇s Hospital of Zhengzhou,Zhengzhou,450006,China)

机构地区：[1]郑州市第七人民医院心内科,郑州450006

出　　处：《临床心血管病杂志》2018年第10期990-992,共3页Journal of Clinical Cardiology

摘　　要：目的:探讨冠心病(CHD)经皮冠状动脉介入治疗(PCI)患者在服用替格瑞洛期间发生呼吸困难的预测因素。方法:选择293例行PCI服用替格瑞洛的CHD患者,58例(19.8%)发生替格瑞洛相关呼吸困难(A组),235例(80.2%)未发生替格瑞洛相关呼吸困难(B组);2组在年龄、性别、吸烟、贫血方面,差异有统计学意义(P<0.05);与未发生出血事件的患者相比,发生出血事件的患者呼吸困难的发生率明显升高(35.3%∶16.5%,单因素分析OR=1.973,P=0.035)。多因素logistic回归分析显示年龄、吸烟、贫血、出血事件与呼吸困难发生呈正相关。结果:结论:PCI治疗的CHD患者应用替格瑞洛出现替格瑞洛相关呼吸困难的风险较高,年龄、吸烟、贫血、出血事件为发生呼吸困难的预测因素。Objective：To investigate the predictors of ticagrelor-related dyspnea in patients with coronary artery disease undergoing percutaneous coronary intervention.Method：Of 293 coronary heart disease（CHD）patients who taking ticagrelor and undergoing percutaneous coronary intervention（PCI）,58 cases（19.8%）showed ticagrelor-related dyspnea and remained 235 cases（80.2%）did not.Between the two groups,age,gender,smoking and anemia were significant different（P〈0.05）.Compared with patients who had no bleeding events,patients with bleeding had significantly increased incidence of dyspnea（35.3%∶16.5%,univariate analysis OR=1.973,P=0.035）.Multivariate logistic regression analysis showed that age,smoking,anemia and bleeding events were positively correlated with dyspnea.Result：Conclusion：There is a high risk of ticagrelor-related dyspnea in patients with coronary artery disease treated with percutaneous coronary intervention.Age,smoking,anemia and bleeding events are predictors of dyspnea.

关 键 词：冠心病 替格瑞洛 呼吸困难 

分 类 号：R541.4[医药卫生—心血管疾病]