Toll样受体4与心肌炎症的研究进展  

Research progress of toll-like receptor 4 and myocardial inflammation

作　　者：孔炳辉 苏强[1] KONG Binghui;SU Qiang(Department of Cardiology,the first affiliated Hospital of Guangxi Medical University,Nan-ning,530021,China)

机构地区：[1]广西医科大学第一附属医院心内科,南宁530021

出　　处：《临床心血管病杂志》2018年第10期1024-1027,共4页Journal of Clinical Cardiology

基　　金：国家自然科学基金项目(No:81600283);广西自然科学基金项目(No:2016GXNSFBA380022)

摘　　要：Toll样受体(Toll-like receptors,TLRs)属于模式识别受体(pattern recognition receptors,PRRs),是天然免疫防御系统的一个重要组成部分。Toll样受体4(TLR4)是最早发现的TLRs成员,可介导心肌组织炎症反应,其介导的炎症信号通路在心肌炎、心肌梗死、缺血再灌注损伤中起到关键作用,并且成为新的抗炎治疗靶点。本文对TLR4在心肌炎症中作用的研究进展作一综述。Toll-like receptors（TLRs）are pattern recognition receptors（PRRs）,which are an important part of the innate immune defense system.Toll-like receptor 4（TLR4）is a member of the earliest discovered TLRs and can mediate the inflammatory response of myocardial tissue.Its inflammatory signaling pathway plays a key role in myocarditis,myocardial infarction,ischemia-reperfusion injury,and becomes a new Anti-inflammatory treatment targets.This article reviews the research progress of the role of TLR4in myocardial inflammation.

关 键 词：TOLL样受体4 心肌炎症 信号通路 

分 类 号：R542.21[医药卫生—心血管疾病]