黄连解毒汤治疗阿尔茨海默病作用机制研究进展  

Novel Advances in the Mechanism of HLJDD Treatment for Alzheimer's Disease

作　　者：顾欣如 王宏洁[1] 杨健[1] 司南[1] 赵海誉[1] 方思月 边宝林[1] GU Xinru;WANG Hongjie;YANG Jian(Institute of Chinese Materia Medica,China Academy of Chinese Medical Science,Beijing（100700）,China)

机构地区：[1]中国中医科学院中药研究所,北京100700 [2]北京中医药大学

出　　处：《浙江中医药大学学报》2018年第10期829-835,共7页Journal of Zhejiang Chinese Medical University

基　　金：国家重点基础研究发展计划(973计划)项目(2014CB543003);国家自然科学基金项目(81202904);北京市科技新星计划项目(Z161100004916126);港澳台科技合作专项项目(2015DFM30030)~~

摘　　要：[目的]综合阐述近年来黄连解毒汤治疗阿尔茨海默病(Alzheimer’s disease, AD)作用机制的研究进展。[方法]阿尔茨海默病是一种神经退行性疾病,其发病机制较为复杂。β淀粉样蛋白沉淀而形成的老年斑和tau蛋白过度磷酸化是其主要的病理特征。近年来,关于阿尔茨海默病的机制研究较为深入并形成多种假说。这篇综述总结近几年的相关文献,试图从临床,抗炎、抗氧化、调节脂质代谢和改善肠道微环境等5个方面探讨黄连解毒汤治疗AD的作用机制。[结果]黄连解毒汤能够从改善体内炎症和氧化应激状态,调节脂质代谢和肠道微环境等方面发挥其治疗AD的作用。[结论]黄连解毒汤对AD的治疗机制具有多环节干预、整体改善、使内源性物质达到新的平衡等特点。[Objective] To synthesize the novel advances in the mechanism of Huanglian Jiedu Decoction（HLJDD） treatment for Alzheimer＇s disease.[Methods] Alzheimer disease is a neurodegenerative disease with complex pathogenesis. The hyperphosphorylation of tau and age spots caused by the deposition of beta-amyloid are the main pathological feature. Over the years, the mechanism of Alzheimer＇s disease has been studied deeply and many hypotheses have been formed. In this review, summarizing the relevant literature in recent years, this article tries to explore the mechanism of HLJDD on AD from anti-inflammatory, antioxidant, regulating lipid metabolism, and improving the intestinal microenvironment. [Results] HLJDD can improve inflammation and oxidative stress, regulate lipid metabolism and intestinal microenvironment, and play its role in the treatment of AD. [Conclusion] The treatment mechanism of HLJDD on AD has many individual characteristics with multi-intervention, improving intergrally, and making the endogenous substance to achieve a new balance.

关 键 词：黄连解毒汤 阿尔茨海默病 抗炎 抗氧化 脂质代谢 肠道微环境 综述 

分 类 号：R651[医药卫生—外科学]