社区干预对合并焦虑抑郁的幽门螺杆菌感染患者的疗效研究  

Curative Effect Study of Community Intervention on Helicobacter Pylori Patients with Anxiety and Depression

作　　者：欧阳琦[1] 陈玲[1] 王毅敏[1] 王会颖[1] 刘怡 李月[1] 沈冬云[1] 刘焱[1] 高大勇[1] Ouyang Qi;CHEN Ling;WANG Yi-min;WANG Hui-ying;LIU Yi;LI Yue;SHEN Dong-yun;LIU Yan;GAO Da-yong(Aerospace Center Hospital,Beijing,100049)

机构地区：[1]航天中心医院,北京100049

出　　处：《智慧健康》2018年第18期69-71,共3页Smart Healthcare

基　　金：航天科工集团2016医疗卫生项目(编号:2016-LCYL-006)

摘　　要：目的观察社区干预对合并焦虑抑郁的幽门螺杆菌(Hp)感染患者的疗效研究。方法选取我社区自2014年12月至2015年12月收治的60例符合纳入标准的合并焦虑抑郁的Hp感染患者,按随机数字表随机分为观察组与对照组,对照组采用抗Hp药物治疗(质子泵抑制剂+两种适当抗生素+铋剂合用的四联疗法)治疗2周,观察组在抗Hp药物治疗的基础上,另加社区干预综合治疗96周。比较两组患者停用抗Hp药物4周、48周、96周后Hp复发情况。结果抗Hp治疗后治疗组4周复发、48周复发、96周复发情况分别为1例(3.33%)、3例(10.00%)、3例(10.00%),对照组复发情况为3例(10.00%)、7例(23.33%)、11例(36.67%)。治疗组96周复发率低于对照组,差异有统计意义(P<0.05);与治疗前及对照组相比,治疗组治疗后,治疗组治疗后8周、12周、16周、20周、24周后SAS评分降低,治疗后12周、16周、20周、24周后SDS评分降低,差异有统计意义(P<0.05)。结论社区干预治疗能有效降低合并焦虑抑郁的Hp感染患者2年复发率,持续改善患者焦虑、抑郁状态,可在临床广泛应用。Objective to observe and study curative effect of community intervention on Helicobacter pylori（Hp） infected patients with anxiety and depression. Methods choose 60 cases Hp infected patients with anxiety and depression in accordance with standard in our community from December 2014 to December 2015, divide them into observation and control group according to random number table method. Control group was treated with anti Hp drug therapy（proton pump inhibitor±two appropriate antibiotics±bismuth combined quadruple therapy） for 2 weeks. On the basis of anti Hp drug therapy, observation group was treated with community intervention for 96 weeks. Compare Hp relapse 4, 48 and 96 weeks after anti Hp drugs discontinuation between two groups. Results after anti Hp treatment, recurrence of 4, 48 and 96 weeks of treatment group was 1 case（3.33%）, 3 cases（10.00%） and 3 cases（10.00%）, and that of control group was 3 cases（10.00%）, 7 cases（23.33%）, and 11 cases（36.67%）. Recurrence rate of 96 weeks in treatment group was lower than control group, difference showed statistical significance,（P〈0.05）. Compared with before treatment and control group, SAS scores of treatment group decreased 8, 12, 16, 20 and 24 weeks after treatment, and SDS scores decreased 12, 16, 20, and 24 weeks after treatment, difference showed statistical significance,（P〈0.05）. Conclusion community intervention therapy can reduce two year recurrence rate of Hp infected patients with anxiety and depression effectively, improve anxiety and depression status continuously, which can be widely applied in clinical practice.

关 键 词：幽门螺杆菌 焦虑抑郁状态 社区干预 

分 类 号：R473.2[医药卫生—护理学]