阿片类药物研发近期热点  

Recent Topics in Research and Development of Opioid Drugs

作　　者：潘陈玲 孟浩 汪亮亮 沈悦海[1,2] 左之利 王冠林[1] 张宽仁[1] Pan Chenling;Meng Hao;Wang Liangliang;Shen Yuehai;Zuo Zhili;Wang Guanlin;Chang Kwen-jen(Faculty of Life Science and Technology,Kunming University of Science and Technology,Kunming 650500;State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201;Beijing Computing Center,Beijing Academy of Science and Technology,Beijing 100094;Beijing Beike Deyuan Bio-Pharm Technology Co.,Ltd.,Beijing 100094)

机构地区：[1]昆明理工大学生命科学与技术学院,昆明650500 [2]中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,昆明650000 [3]北京市科学技术研究院北京市计算中心,北京100094 [4]北京北科德源生物医药科技有限公司,北京100094

出　　处：《有机化学》2018年第10期2625-2632,共8页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21772207);中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室开放课题(No.P2015-KF04)资助项目~~

摘　　要：阿片类药物广泛用于临床,但存在呼吸抑制、成瘾性等诸多副作用,因此阿片类药物研发一直受到广泛关注.近年来相关基础研究的进展为新机制阿片类药物研究提供了重要线索.对小分子阿片类药物的近期研究热点进行了总结.Opioid drugs are widely used in clinical practice, but they are also notorious for their respiratory depression and addictive side effects. Therefore, tremendous efforts have been paid to the research and development of opioid drugs. Recent progresses in related research fields provide important clues for developing opioid drugs with novel mechanisms. Recent reports on several topics in the study of small molecule opioid drugs are summarized.

关 键 词：阿片药物 阿片受体 阿片样副作用 药物研究 

分 类 号：TQ460.1[化学工程—制药化工]