不同支化结构的聚酰胺胺的合成、活性及其在基因载体中的应用（英文）  

Poly(amido amine)s with Different Branched Architecture: Synthesis, Reactivity and Their Application in Gene Delivery

作　　者：张薇[1] 姚子健 邓维[1,2] Zhang Wei;Yao Zijian;Deng Wei(School of Materials Science and Engineering,Shanghai University,Shanghai 200444;School of Chemical and Engineering,Shanghai Institute of Technology,Shanghai 201418)

机构地区：[1]上海大学材料科学与工程学院,上海200444 [2]上海应用技术大学化学与环境工程学院,上海201418

出　　处：《有机化学》2018年第10期2713-2719,共7页Chinese Journal of Organic Chemistry

基　　金：Project supported by the Key Subject of Shanghai Municipal Education Commission(No.J50704);the Natural Science Foundation of Shanghai City(No.16ZR1435700)~~

摘　　要：具有不同拓扑结构的聚酰胺胺是基因载体和药物传递的理想选择.报道了一系列具有相同重复单元,但是支化度不同的聚酰胺胺.通过N,N-亚甲基二(丙烯酰胺)(MBA)和L-半胱氨酸甲酯盐酸盐(CYS)在水/二甲基亚砜的共溶剂中的Michael加成缩聚反应,成功地制备出了不同支化度的聚酰胺胺.制备的阳离子聚酰胺胺(PAAs)具有良好的DNA复合能力.Poly（amido amine）s with diverse topographical structures are promising candidates for gene delivery and drug carriers. A series of poly（amido amine）s（PAAs） with the same repeating units, however, different degree of branching, were successfully prepared by Michael addition polycondensation of N,N-methylenebis（acrylamide）（MBA） and L-cysteine methyl ester hydrochloride（CYS） in a water/dimethyl sulfoxide co-solvent. The obtained disposed cationic PAAs exhibit good DNA condensation capacities.

关 键 词：聚酰胺胺 支化聚合物 基因载体 L-半胱氨酸甲酯盐酸盐 环糊精 

分 类 号：O633.22[理学—高分子化学]