铜催化醛肟脱水/贝克曼重排选择性可切换反应（英文）  

Copper-Catalyzed Selectivity-Switchable Dehydration/Beckmann Rearrangement Reactions of Aldoxime

作　　者：范昕 易容 王芳[3] 张旭[1,2] 徐清 俞磊 Fan Xin;Yi Rong;Wang Fang;Zhang Xu;Xu Qing;Yu Lei(Guangling College,Yangzhou University,Yangzhou 225000;School of Chemistry and Chemical Engineering,Yangzhou University,Yangzhou 225002;Yangzhou Polytechnology Institute,Yangzhou 225127)

机构地区：[1]扬州大学广陵学院,扬州225000 [2]扬州大学化学化工学院,扬州225002 [3]扬州工业职业技术学院,扬州225127

出　　处：《有机化学》2018年第10期2736-2740,共5页Chinese Journal of Organic Chemistry

基　　金：Project supported by the National Natural Science Foundation of China(No.21202141);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);the Natural Science Foundation of Guangling College(No.ZKZD17005)~~

摘　　要：廉价金属铜,可催化醛肟的脱水反应,生成有机腈.该反应在腈类溶剂中发生,并且使用二氧化锰作助催化剂,三苯基膦作配体.如果使用水作溶剂,则会发生贝克曼重排,生成酰胺.这种选择性随溶剂切换的有趣反应,为合成相关有用的有机化合物提供了简便方法,兼具学术与实用价值.It was found that, copper as a cheap metal, could well catalyze the dehydration reaction of aldoximes to organonitriles in nitrile solvent by using MnO2 as the co-catalyst and PPh3 as the ligand. In contrast, instead of organonitriles, the Cu-catalyzed reactions of the aldoximes in water led to amides, which were the products of the Beckmann rearrangements. These interesting selectivity-switchable reactions afford easy accesses to the related useful organic compounds and may be of both academic and practical values.

关 键 词：醛肟 脱水 贝克曼重排 腈 酰胺 

分 类 号：O621.251[理学—有机化学]