通过C(sp^3)—H键直接官能团化高效合成1-芳基烯基膦酸酯（英文）  

An Efficient Synthesis of 1-Arylvinylphosphonates via Direct Functionalization of C(sp^3)—H Bond

作　　者：任林静[1] 冉茂刚 方学红[1] 赵玲[1] 姚秋丽[1] Ren Linjing;Ran Maogang;Fang Xuehong;Zhao Ling;Yao Qiuli(School of Pharmacy,Zunyi Medical University,Zunyi 5630)

机构地区：[1]遵义医学院药学院,遵义56300

出　　处：《有机化学》2018年第10期2791-2797,共7页Chinese Journal of Organic Chemistry

基　　金：Project supported by the National Natural Science Foundation of China(Nos.21462056,21801261);the Science and Technology Foundation of Guizhou Province(No.[2014]7542);he Zunyi Medical University(Nos.20163715,F-627)~~

摘　　要：直接对磷酰基邻位的C(sp3)—H键进行官能团化来合成烯基膦酸酯的研究非常少见.通过苄基膦酸酯与多聚甲醛在温和的碱性条件下,使用四叔丁基碘化铵催化可以在空气中高效简便地合成烯烃膦酸酯,底物适用范围广,可获得中等至优秀的产率.The direct functionalization of the C（sp3）—H bond adjacent to the phosphonate group for the preparation of vinyl phosphonates was rarely developed. Herein, a simple and efficient tetrabutylammonium iodide catalyzed protocol for the preparation of vinyl phosphonates from benzylic phosphonates and paraformaldehyde is achieved under mild conditions in air. Moderate to high yields can be obtained for a broad scope of substrates.

关 键 词：膦酸酯 烯烃化 C(sp3)—H键官能团化 Horner-Wadsworth-Emmons反应 

分 类 号：O627.51[理学—有机化学]