NKX2.5基因63A>G多态性与先天性心脏病相关性的Meta分析  

Associations of NKX2.5 63A>G genetic polymorphisms with the risk of congenital heart disease:a Meta-analysis

作　　者：谢华斌 马芳芳 XIE Hua-bin;MA Fang-fang(Department of Clinical Laboratory,Xiamen Cardiovascular Hospital,Xiamen University,Xiamen,Fujian Province,361004,China)

机构地区：[1]厦门大学附属心血管病医院检验科,福建厦门361004

出　　处：《中国优生与遗传杂志》2018年第10期17-20,共4页Chinese Journal of Birth Health & Heredity

基　　金：厦门市科技惠民项目3502Z20174009

摘　　要：目的探讨NKX2-5基因63A>G多态性与先天性心脏病易感性的关系。方法从数据库Pub Med、Medline、CNKI及WanFangData网站上检索并收集相关人群NKX2-5基因63A>G多态性与先天性心脏病易感性的病例-对照研究,检索时限截至2018年3月。按照纳入与排除标准筛选文献、提取资料并评价纳入研究的质量后,用Stata12.0软件进行Meta分析、发表偏倚评估和敏感性分析。结果共10篇纳入研究。NKX2-5基因63A>G多态性与先天性心脏病易感性相关研究中,共有先心病患者1725例,对照组1650例。经Meta分析结果显示NKX2-5基因63A>G多态性与先天性心脏病的相关性在5个遗传模型中都没有统计学意义(P>0.05)。等位基因模型(Gvs.A:OR=1.028,95%CI=0.945-1.117,P=0.524;P_(heterogeneity)<0.001,I2=75.5%);显性遗传模型(GG+GA vs. AA:OR=1.006,95%CI=0.949-1.066,P=0.845;P_(heterogeneity)<0.001,I2=71.1%);隐性遗传模型(GG vs. AA+GA:OR=1.056,95%CI=0.968-1.152,P=0.222;P_(heterogeneity)=0.119,I2=36.2%);纯合子模型(GGvs.AA:OR=1.009,95%CI=0.915-1.112,P=0.863;P_(heterogeneity)=0.008,I2=59.9%);杂合子模型(GAvs.AA:OR=1.001,95%CI=0.918-1.092,P=0.978;P_(heterogeneity)=0.010,I2=58.7%)。结论 NKX2-5基因63A>G多态性可能不是先天性心脏病的危险因素。Objective：To evaluate the associations between polymorphisms of NKX2.5 63 AG and risk of congenital heart disease. Methods：Collect related crowd NKX2.5 63 AG polymorphism and the risk of CHD in the case-control study through the following electronic databases：PubMed,Medline,CNKI and WanFang data up to March 2018. Meta-analysis,publication bias and sensitivity analysis were performed using Stata statistical software12.0. Results：A total of 10 relevant articles were selected. 10 case-control studies containing 1725 cases of congenital heart disease and 1650 controls were included in the analysis of NKX2.5 63 AG and risk of CHD. Our results revealed that the polymorphic frequency distribution of NKX 2.5 63 AG in CHD cases were not statistically different from that in healthy controls（P〈0.05）in five models. In the allelomorph model（G vs. A：OR=1.028,95%CI=0.945-1.117,P=0.524;Pheterogeneity〈0.001,I^2=75.5%）;in the dominant inheritance model（GG＋GA vs. AA：OR=1.006,95% CI=0.949-1.066,P=0.845;Pheterogeneity〈0.001,I^2 =71.1%）;in the recessive inheritance model（GG vs. AA＋GA：OR=1.056,95%CI=0.968-1.152,P=0.222;Pheterogeneity=0.119,I^2=36.2%）;in the homozygote model（GG vs. AA：OR=1.009,95%CI=0.915-1.112,P=0.863;Pheterogeneity=0.008,I^2=59.9%）and in the heterozygote model（GA vs. AA：OR=1.001,95%CI=0.918-1.092,P=0.978;P_（heterogeneity ）=0.010,I^2 =58.7%）. Conclusion：Our findings suggested that NKX2-563 AG polymorphism may not be implicated in the pathogenesis of CHD.

关 键 词：NKX2.5 多态现象 先天性心脏病 META分析 

分 类 号：R541.1[医药卫生—心血管疾病]