紫黄生肌膏促进高位复杂性肛瘘术后创面愈合的临床研究  

Clinical study on Zihuang Shengji Ointment in promoting postoperative wound healing of highly complicated anal fistula

作　　者：何宗琦[1] 文科[1] 王晓鹏[1] 甄曙光[1] 孙薛亮[1] 杨建华[1] HE Zong-qi;WEN Ke;WANG Xiao-peng;ZHEN Shu-guang;SUN Xue-liang;YANG Jian-hua(Department of Anorectal,Suzhou Hospital of Chinese Medicine,Suzhou Affiliated Hospital of Nanjing University of Chinese Medicine,Suzhou 215009,Jiangsu,CHINA)

机构地区：[1]苏州市中医医院南京中医药大学苏州附属医院肛肠科,江苏苏州215009

出　　处：《海南医学》2018年第20期2856-2858,共3页Hainan Medical Journal

基　　金：江苏省苏州市科技局应用基础研究项目(编号:SYS201574)

摘　　要：目的观察紫黄生肌膏外敷伤口对高位复杂性肛瘘术后创面愈合的临床疗效及安全性。方法采用队列研究方法将63例苏州市中医医院2015年1月至2017年8月间收治的高位复杂性肛瘘术后患者分为观察组(n=33)和对照组(n=33),观察组换药时采用浸有紫黄生肌膏的纱布外敷创面,对照组应用凡士林纱布覆盖创面。通过观察术后不同时期患者创面愈合率、创面愈合时间、创面疼痛情况及治疗期间有无不良事件出现等评价紫黄生肌膏的临床疗效及安全性。结果两组患者术后均随访6个月,63例患者肛瘘切口均在60 d内愈合,其中有2例复发;两组患者均完成全部随访观察指标,无不良事件发生。比较两组术后第7天的主切口创面愈合率,观察组为(23±2.28)%,对照组为(21±1.14)%,差异无统计学意义(P>0.05);观察组患者术后第14天和第30天的主切口创面愈合率分别为(51±4.45)%和(95±2.43)%,均明显高于对照组的(40±2.97)%和(82±4.15)%,差异均有统计学意义(P<0.05);观察组患者术后第1天的疼痛评分为(2.23±0.37)分,与对照组的(2.36±0.51)分比较差异无统计学意义(P>0.05);观察组患者术后第7天的第14天的疼痛评分分别为(1.24±0.74)分和(0.51±0.32)分,明显低于对照组的(1.78±0.44)分和(1.06±0.83)分,差异均有统计学意义(P<0.05);观察组患者术后主切口创面愈合时间为(36±1.74) d,明显短于对照组的(45±2.16) d,差异有统计学意义(P<0.05)。结论高位复杂性肛瘘术后换药时应用紫黄生肌药膏能减轻患者术后伤口疼痛、促进创面愈合,能缩短创面愈合时间,且安全性好,值得临床推广应用。Objective To observe the clinical efficacy and safety of external application of Zihuang Shengji Ointment in the treatment of wound healing after high complex anal fistula. Methods A total of 63 patients with high-complex anal fistula, admitted to Suzhou Hospital of Chinese Medicine from January 2015 to August 2017, were divided into the observation group（n=33） and control group（n=30） by using the cohort study method. The gauze soaked with Zihuang Shengji Ointment was used to the wound surface in the observation group, and Vaseline gauze was used in the control group. The wound healing rate, wound healing time, wound pain and adverse events were observed to evaluate the clinical efficacy and safety of Zihuang Shengji Ointment during the treatment. Results All the patients were followed up for 6 months. All the 63 patients underwent anal fistula incision within 60 days, two of them relapsed. All the patients completed all follow-up observations and no adverse events occurred. The wound healing rate of the main incision on the 7 thday after operation in the observation group was（23 ± 2.28）% versus（21 ± 1.14）% in the control group（P〈0.05）. The wound healing rates of the main incision on the 14 thday and 30 thday in the observation group were（51±4.45）% and（95±2.43）%, respectively, which were significantly higher than corresponding（40±2.97）% and（82±4.15）% of the control group（P〈0.05）. The pain scores on the 1 stpostoperative day in the observation group and the control group were respectively（2.23±0.37） and（2.36±0.51）, with no significant difference（P〈0.05）. The pain scores on the 7 thday and 14 thday after operation in the observation group were（1.24±0.74） and（0.51±0.32）, which were significantly lower than corresponding（1.78±0.44） and（1.06±0.83） in the control group（P〈0.05）. The average healing time of the observation group was（36±1.74） days versus（45±2.16） days of the control group（P〈0.05）. Conclusion Zihuang

关 键 词：紫黄生肌膏 高位复杂性肛瘘 创面愈合 

分 类 号：R657.16[医药卫生—外科学]