甲基泼尼松龙冲击治疗小儿激素敏感肾病综合征的临床分析  

Clinical Analysis of Methylprednisolone in the Treatment of Pediatric Hormone-Sensitive Nephrotic Syndrome

作　　者：莫筱玮 MO Xiao-Wei(Special Clinic Outpatient Department,Guangzhou First People＇s Hospital,Guangzhou,Guangdong Province,510000 China)

机构地区：[1]广州市第一人民医院门诊部特诊室,广东广州510000

出　　处：《系统医学》2018年第20期107-108,131,共3页Systems Medicine

摘　　要：目的对甲基泼尼松龙冲击治疗小儿激素敏感肾病综合征的临床效果作探讨。方法此次将2016年1月—2017年12月作为研究时间段,于期间随机抽取该院收治的激素敏感肾病综合征患儿84例为对象,将其以双盲法均分为两组:42例对照组患儿接受泼尼松口服治疗,42例观察组患儿接受甲基泼尼松龙冲击治疗;详细整理两组患儿临床治疗情况,将所获数据作对比分析。结果观察组患儿尿蛋白转阴时间(5.17±1.35)d比对照组(9.73±1.56)d短(t=6.932 1,P<0.05);观察组患儿治疗缓解率97.6%比对照组83.3%高(χ~2=5.160 4,P<0.05);观察组患儿3个月内复发率7.1%比对照组33.3%低(χ~2=7.385 1,P<0.05);观察组患儿体质量(34.10±4.37)kg/m^2、腹部脂肪厚度(10.52±2.14)mm、二头肌脂肪厚度(7.98±0.62)mm、骨密度(0.59±0.00)g/cm^2等指标数值比对照组优,(t=11.750 3、10.041 5、9.571 0、5.879 3,P<0.05);两组患儿用药期间均未见严重不良反应。结论激素敏感肾病综合征患儿接受甲基泼尼松龙冲击治疗的效果更佳。Objective To investigate the clinical effect of methylprednisolone on the treatment of steroid-induced nephrotic syndrome in children. Methods From January 2016 to December 2017, the study period was used. During the period, 84 children with steroid-sensitive nephrotic syndrome admitted to the hospital were randomly selected. They were divided into two groups by double-blind method： Forty-two patients in the control group received oral prednisone treatment, and 42 patients in the observation group received methylprednisolone shock therapy. The clinical treatment of the two groups was detailed and the data were compared. Results In the observation group, the time of urinary pro- tein conversion （5.17±1.35） d was shorter than that of the control group （9.73±l.56）d,（t=6.932 1, P〈0.05）. The treat- ment remission rate of the observation group was 97.6% higher than that of the control group 83.3% （χ2=5.160 4, P〈 0.05）; the recurrence rate of 7.1% in the observation group was lower than that in the control group by 33.3%（χ2= 7.385 1, P〈0.05）; the body mass of the observation group （34.10e4.37）kg/m2, abdomen fat thickness （10.52e2.14） ram, biceps fat thickness （7.98±0.62） ram, bone density （0.59±0.00） g/χ2 and other indicators are better than the control group （t= 11.750 3,10.041 5,9.571 0,5.879 3, P〈0.05 ）; no serious adverse reactions were observed during the two groups of children. Conclusion Children with hormone-sensitive nephrotic syndrome are more effective in receiving methyl- prednisolone shock therapy.

关 键 词：小儿 激素敏感肾病综合征 甲基泼尼松龙 冲击治疗 

分 类 号：R726.9[医药卫生—儿科]