济宁市狂犬病潜伏期影响因素研究  

Influence factors for rabies incubation period in Jining City

作　　者：段伟[1] 颜丙新[1] 刘伟[1] 孙喜红[1] 崔秀举 鲁希茜 姜文国[1] DUAN Wei;YAN Bing-xin;LIU Wei;SUN Xi-hong;CUI Xiu-ju;LU Xi-xi;JIANG Wen-guo(Jining Center for Disease Control and Prevention,Shandong 272000,China)

机构地区：[1]济宁市疾病预防控制中心,山东济宁272000

出　　处：《上海预防医学》2018年第10期848-851,共4页Shanghai Journal of Preventive Medicine

基　　金：山东省济宁市科技计划项目(jk-2015-57-45)

摘　　要：【目的】探讨狂犬病潜伏期的影响因素,为制定狂犬病防控策略,延长狂犬病潜伏期提供依据。【方法】对2006—2015年济宁市报告的87例狂犬病病例开展流行病学调查并进行分析。采用单因素分析(Mann-whitney U检验和Kruskal-Wallis秩和检验)及多因素分析(Cox比例风险回归模型)研究狂犬病潜伏期的影响因素。【结果】狂犬病潜伏期为3～7 345 d,平均潜伏期为65 d。单因素分析显示,暴露部位、暴露分级、暴露后免疫史、伤人动物种类4个因素对狂犬病潜伏期的影响有统计学意义(P<0. 05);多因素分析显示,暴露后免疫史、暴露分级、暴露部位是狂犬病潜伏期的影响因素,暴露后免疫接种者发病风险是未免疫者的17. 48倍,头面部暴露者的发病风险是下肢暴露者的2. 13倍。【结论】暴露后免疫史、暴露分级、暴露部位是狂犬病潜伏期的影响因素。[ Objective ] To explore the influence factors of rabies incubation period, anti provide scientific evidence for prevention and control of rabies and prolongation of incubation period. [ Methods ] Epidemiological data on human rabies eases of Jining City occurring during 2006-2015 were collected. Univariate analysis and Cox proportional hazard regression analysis were used targeting at the influence factors for incubation period of rabies eases. [ Results] The study investigated a total of 87 eases, with average rabies incubation period being 65 days （ranging from 3 to 7 345 days ）. Single variable analysis showed that exposure grading, exposed sites, postexposure immune histoU ant] hurt animal species were related to the rabies incubation period with statistical significance（P〈0.05）. Cox proportional hazard regression showed that postexposure immune history, exposure grading and exposed sites were the real factors influeneing latent period. The onset risk of vaccinated presons was 17.48 times that of unvaccinated persons. The onset risk of exposure to headand face was 2. 13 times that of lower limb exposure. [ Conclusion ] The determinants affecting incubation period of rabies prove to be postexposure vaccination, exposure grading and exposed sites.

关 键 词：狂犬病 潜伏期 影响因素 

分 类 号：R512.99[医药卫生—内科学]