原发性高血压患者醛固酮与肾素比值与夜间血压的关系  

Relationship between aldosterone/renin ration and nighttime blood pressure in essential hypertension

作　　者：王洪岐[1] 于海涵 潘宇[3] 韩旭春 WANG Hongqi;YU Haihan;PAN Yu;HAN Xuchun(Department of Clinical Laboratory,Beijing Changping Hospital,Beijing 102200,China;Community Health Service Center of Haidian District Huayuan Road,Beijing 100080,China;Department of Endocrine,Beijing Chang ping Hospital,Beijing 102200,China)

机构地区：[1]北京市昌平区医院检验科,北京102200 [2]北京市海淀区花园路社区卫生服务中心,北京100080 [3]北京市昌平区医院内分泌科,北京102200

出　　处：《国际检验医学杂志》2018年第22期2813-2816,共4页International Journal of Laboratory Medicine

基　　金：北京市自然科学基金资助项目(7140141)

摘　　要：目的探讨原发性高血压患者醛固醇与肾素比值(ARR)与夜间血压的关系。方法收集2016年12月至2017年12月该院收治的113例原发性高血压患者为研究对象,根据ARR的中位数值将其分为ARR低水平组(n=51)和ARR高水平组(n=62),比较两组患者日间血压如日间收缩压(DSBP)、日间舒张压(DDBP),夜间血压如夜间收缩压(NSBP)、夜间舒张压(NDBP),同时收集血钾、血钠水平。结果 ARR高水平组NSBP、NDBP、血钠水平高于ARR低水平组,血钾水平低于ARR低水平组,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,NSBP、NDBP、血钠是ARR升高的独立危险因素(OR=1.242、1.397、1.214,P<0.05),血钾是ARR升高的保护因素(OR=0.744,P<0.05)。Spearman秩相关分析结果显示,ARR与NSBP、NDBP、血钠呈正相关性(r=0.317、0.336、0.329,P<0.05),与血钾呈负相关性(r=-0.621,P<0.05)。结论夜间血压升高是原发性高血压患者ARR升高的独立危险因素。Objective To explore the relationship between aldosterone to renin ratio （ARR） and nighttime blood pressure in essential hypertension. Methods A total of 113 patients with essential hypertension in the hospital from December 2015 to December 2017 were enrolled in the study, and were divided into ARR low level group （n=51） and ARR high level group （n=62） according to the median of ARR. The comparisons of daytime systolic blood pressure （DSBP）, daytime diastolic blood pressure （DDBP）, nighttime systolic blood pressure （NSBP）, nighttime diastolic blood pressure （NDBP） were conducted. And the serum potassium, ser um sodium levels were compared. Results The NSBP, NDBP, serum sodium levels of ARR high level group were high than those of ARR low level group, and serum potassium level was low than that of ARR low level group,and the difference was statistically significant （P〈0. 05）. Multivariate logistic regression analysis showed that NSBP,NDBP,serum sodium were independent risk factors of high ARR （OR = 1. 242,1. 397, 1. 214,P〈0.05）,and serum potassium was the protective factor of ARR （OR=0. 744,P〈0.05）. Spearman rank correlation analysis showed that ARR was positively correlated with NSBP, NDBP and serum sodium （r=0. 317,0.336,0.329,P〈0. 05）,and ARR was negatively associated with serum potassium （r= 0. 621, P〈0. 05）. Conclusion Nighttime elevated blood pressure is an independent risk factor for elevated ARR in patients with essential hypertension.

关 键 词：原发性高血压 醛固酮 肾素 夜间血压 

分 类 号：R544.1[医药卫生—心血管疾病]