初诊白细胞计数与儿童高白细胞急性淋巴细胞白血病预后的关系  

The Relationship between Initial Leukocyte Count and Prognosis of Pediatric with Hyperleukocytic Acute lymphoblastic Leukemia

作　　者：杨小燕[1] 金皎[1] 黄璟[1] 许键炜[2] 吴西军 吴昌学[3,4] 吴莎莎[1] 马健娟[1] 李燕[1] 庹媛媛 杨红兰[1] 潘海新 何志旭[1,2] 胡绍燕[5] YANG Xiaoyan;JIN Jiao;HUANG Jing;XU Jianwei;WU Xijun;WU Changxue;WU Shasha;MA Jianjuan;LI Yan;TUO Yuanyuan;YANG Honglan;PAN Haixin;HE Zhixu;HU Shaoyan(Department of Pediatrics,The Affiliated Hospital of Guizhou Medcial University,Guiyang 550004,Guizhou,China;Tissue Engineering and Stem Cell Research Center,Guizhou Medcial University,Guiyang 550004,Guizhou,China;The Key Laboratory of Molecular Biology,Guizhou Medcial University,Guiyang 550004,Guizhou,China;The Key Laboratory of Endemic and Ethnic Disease,Guizhou Medcial University,Guiyang 550004,Guizhou,China;Children＇s Hospital of Soochow University,Suzhou 215000,Jiangsu,China)

机构地区：[1]贵州医科大学附院儿科,贵州贵阳550004 [2]贵州医科大学干细胞与组织工程实验中心,贵州贵阳550004 [3]贵州医科大学分子生物学重点实验室,贵州贵阳550004 [4]贵州医科大学地方病与少数民族性疾病教育部重点实验室,贵州贵阳550004 [5]苏州大学附属儿童医院,江苏苏州215000

出　　处：《贵州医科大学学报》2018年第11期1311-1314,共4页Journal of Guizhou Medical University

基　　金：贵州省科技厅联合基金[黔科合LH(2016)7240号];贵州省科技计划项目[黔科合LG字(2012)009号];贵州医科大学附院博士基金

摘　　要：目的:研究初诊外周血白细胞(WBC)计数与儿童高白细胞急性淋巴细胞白血病(HALL)预后的关系。方法:HALL患儿121例,按照WBC计数分为WBC≥300×109/L组和<300×109/L组,比较两组患儿的总生存率、无事件生存率及复发率。结果:初诊时WBC≥300×109/L组HALL患儿无事件生存率低于WBC <300×109/L组(P=0. 034),复发率高于WBC <300×109/L组(P=0. 026),但两组总生存率比较,差异无统计学意义(P=0. 147)。结论:初诊时外周血WBC≥300×109/L的HALL患儿无事件生存率低、复发率高。Objective：To study the relationship between initial white blood cell （WBC） count and the prognosis of pediatric with hyperleukocytic acute lymphocytic leukemia （HALL）. Methods： 121 children with HALL were divided into two groups： the group with WBC≥300×10^9/L and the group with WBC〈300×10^9/L according to the initial diagnosis. The data of the patients were retrospectively analyzed. SPSS 18.0 was employed to detect the overall survival rate （OS）, events free survival （EFS） and relapse rates. Results： The estimated 5-year EFS was lower and the elapse rate was higher in the group with WBC≥300×10^9/L than those in the group with WBC〈300×10^9/L （ P =0.034 and P =0.026 retrospectively）. But no difference was found in OS between the two groups. Conclusions： The initial WBC count over 300×10^9/L is significantly associated with lower EFS rates and higher relapse rates.

关 键 词：儿童 白血病 淋巴样 高白细胞 白细胞计数 无事件生存率 复发率 

分 类 号：R446[医药卫生—诊断学]