Helicobacter pylori and allergy: Update of research  

作　　者：Ilva Daugule Jelizaveta Zavoronkova Daiga Santare 

机构地区：[1]Faculty of Medicine, University of Latvia

出　　处：《World Journal of Methodology》2015年第4期203-211,共9页世界方法学杂志

摘　　要：Recently a lot of literature has been published about the possible preventive action of Helicobacter pylori(H. pylori) against allergy. The present review summarizes research data about the association between H. pylori and allergic diseases, as well as discusses possible hypotheses about the preventive action of H. pylori against atopy. There is evidence from observational studies to support a weak inverse association between prevalence of H. pylori infection and allergy. However, confounders like some unidentified socioeconomic factors, antibiotic use and others could bias the association. Although data from cohort studies point to a possible association of H. pylori with some of the allergic diseases, no definite proof for causal relationship has been clearly demonstrated yet. A biological mechanism proposed to explain the preventive action of H. pylori to allergy is reduced exposure to a major stimulus for the generation of Treg cells in individuals without H. pylori infection. In addition, H. pylori could be an indicator for changes in gut microbiome, reflecting the complex interaction between microbes and immune system.Recently a lot of literature has been published about the possible preventive action of Helicobacter pylori （H. pylori ） against allergy. The present review summarizes research data about the association between H. pylori and allergic diseases, as well as discusses possible hypotheses about the preventive action of H. pylori against atopy. There is evidence from observational studies to support a weak inverse association between prevalence of H. pylori infection and allergy. However, confounders like some unidentified socioeconomic factors, antibiotic use and others could bias the association. Although data from cohort studies point to a possible association of H. pylori with some of the allergic diseases, no defnite proof for causal relationship has been clearly demonstrated yet. A biological mechanism proposed to explain the preventive action of H. pylori to allergy is reduced exposure to a major stimulus for the generation of Treg cells in individuals without H. pylori infection. In addition, H. pylori could be an indicator for changes in gut microbiome, refecting the complex interaction between microbes and immune system.

关 键 词：HELICOBACTER PYLORI ALLERGY ATOPY 

分 类 号：O1[理学—数学]