Primary focal and segmental glomerulosclerosis and soluble factor urokinase-type plasminogen activator receptor  

作　　者：Hernán Trimarchi 

机构地区：[1]Servicio de Nefrología, Hospital Británico de Buenos Aires

出　　处：《World Journal of Nephrology》2013年第4期103-110,共8页世界肾病学杂志（英文版）

摘　　要：Primary focal and segmental glomerulosclerosis(FSGS) may be due to genetic or acquired etiologies and is a common cause of nephrotic syndrome with high morbidity that often leads to end-stage renal failure. The different available therapeutic approaches are unsuccessful, in part due to partially deciphered heterogeneous and complex pathophysiological mechanisms. Moreover, the term FSGS, even in its primary form, comprises a histological description shared by a number of different causes with completely different molecular pathways of disease. This review focuses on the latest developments regarding the pathophysiology of primary acquired FSGS caused by soluble factor urokinase type plasminogen activator receptor, a circulating permeability factor involved in proteinuria and edema formation, and describes recent advances with potential success in therapy.Primary focal and segmental glomerulosclerosis （FSGS） may be due to genetic or acquired etiologies and is a common cause of nephrotic syndrome with high morbid-ity that often leads to end-stage renal failure. The differ-ent available therapeutic approaches are unsuccessful, in part due to partially deciphered heterogeneous and com-plex pathophysiological mechanisms. Moreover, the term FSGS, even in its primary form, comprises a histological description shared by a number of different causes with completely different molecular pathways of disease. This review focuses on the latest developments regarding the pathophysiology of primary acquired FSGS caused by soluble factor urokinase type plasminogen activa-tor receptor, a circulating permeability factor involved in proteinuria and edema formation, and describes recent advances with potential success in therapy.

关 键 词：Primary acquired focal and segmental glomerulosclerosis Soluble factor urokinase type plasminogen activator receptor Proteinuria Podocyte Plasmin 

分 类 号：R692[医药卫生—泌尿科学] R692.5[医药卫生—外科学]