Potential ability of xanthophylls to prevent obesityassociated cancer  

作　　者：Masaru Terasaki Michihiro Mutoh Gen Fujii Mami Takahashi Rikako Ishigamori Sonoko Masuda 

机构地区：[1]Department of Health and Environmental Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan [2]Division of Cancer Prevention Research, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan [3]Central Animal Division, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan

出　　处：《World Journal of Pharmacology》2014年第4期140-152,共13页世界药理学杂志

基　　金：Supported by National Cancer Center Research and Development Fund No.25-A-15;The Research Grant of the Princess Takamatsu Cancer Research Fund

摘　　要：Obesity-associated cancers, including colon cancer and breast cancer, are increasing in Asian countries with Westernized lifestyles as exemplified by reduced physical activity and increased fat/sugar consumption. An excessive accumulation of visceral adipose tissue causes insulin resistance, dyslipidemia and adipocytokine imbalance, and these factors are suggested to be involved in cancer promotion. To prevent obesityassociated cancers, researcher attention is increasing on the so-called "functional foods". In addition, new approaches to cancer control are in high demand, and using "functional foods" as supplemental or adjuvant agents in chemotherapy is thought to be a promising approach. One of these functional ingredients is xanthophylls, which are natural fat-soluble pigments found in fruits, vegetables, algae and other plants. Xanthophylls belong to the carotenoid class and have struc-tures containing oxygen. Some studies have revealed that xanthophylls improve the inflammation status, serum triglyceride levels, blood pressure levels and liver function test values. Furthermore, recent studies show that xanthophylls possess high anti-cancer, antidiabetic, anti-obesity and anti-oxidant properties. In this review, we highlight the recent findings for five xanthophylls, namely astaxanthin, β-cryptoxanthin, fucoxanthin, neoxanthin and zeaxanthin/lutein, and their relevance to cancer prevention.Obesity-associated cancers, including colon cancer and breast cancer, are increasing in Asian countries with Westernized lifestyles as exemplified by reduced physical activity and increased fat/sugar consumption. An excessive accumulation of visceral adipose tissue causes insulin resistance, dyslipidemia and adipocy-tokine imbalance, and these factors are suggested to be involved in cancer promotion. To prevent obesity-associated cancers, researcher attention is increasing on the so-called “functional foods”. In addition, new approaches to cancer control are in high demand, and using “functional foods” as supplemental or adjuvant agents in chemotherapy is thought to be a promising approach. One of these functional ingredients is xanthophylls, which are natural fatsoluble pigments found in fruits, vegetables, algae and other plants. Xantho-phylls belong to the carotenoid class and have structures containing oxygen. Some studies have revealed that xanthophylls improve the inflammation status, serum triglyceride levels, blood pressure levels and liver function test values. Furthermore, recent studies show that xanthophylls possess high anti-cancer, anti-diabetic, anti-obesity and anti-oxidant properties. In this review, we highlight the recent findings for five xanthophylls, namely astaxanthin, β-cryptoxanthin, fu-coxanthin, neoxanthin and zeaxanthin/lutein, and their relevance to cancer prevention.

关 键 词：Cancer prevention XANTHOPHYLLS 

分 类 号：R589.2[医药卫生—内分泌]