Outcomes of renal transplant recipients with BK virus infection and BK virus surveillance in the Auckland region from 2006 to 2012  

作　　者：Chun-Yuan Hsiao Helen L Pilmore Lifeng Zhou Janak R de Zoysa 

机构地区：[1]Department of Renal Medicine,Middlemore Hospital,Counties Manukau District Health Board,Auckland 1640,New Zealand [2]Department of Renal Medicine,Auckland District Health Board,Auckland 1142,New Zealand [3]the University of Auckland,Auckland 1010,New Zealand [4]Planning,Funding and Outcomes Unit,Waitemata and Auckland District Health Boards,Auckland 0740,New Zealand [5]Department of Renal Medicine,North Shore Hospital,Waitemata District Health Board,Auckland 0740,New Zealand [6]Waitemata Clinical School,the University of Auckland,Auckland 0740,New Zealand

出　　处：《World Journal of Nephrology》2016年第6期497-506,共10页世界肾病学杂志（英文版）

摘　　要：AIM To evaluate incidence, risk factors and treatment outcome of BK polyomavirus nephropathy(BKVN) in a cohort of renal transplant recipients in the Auckland region without a formal BK polyomavirus(BKV) surveillance programme.METHODS A cohort of 226 patients who received their renal transplants from 2006 to 2012 was retrospectively reviewed.RESULTS Seventy-six recipients(33.6%) had a BK viral load(BKVL) test and 9 patients(3.9%) developed BKVN. Cold ischaemia time(HR = 1.18, 95%CI: 1.04-1.35) was found to be a risk factor for BKVN. Four recipients with BKVN had complete resolution of their BKV infection; 1 recipient had BKVL less than 625 copies/mL; 3 recipients had BKVL more than 1000 copies/mL and 1 had graft failure from BKVN. BKVN has a negative impact on graft function [median estimated glomerular filtration rate(eG FR) 22.5(IQR 18.5-53.0) mL /min per 1.73 m^2, P = 0.015), but no statistically significant difference(P = 0.374) in renal allograft function was found among negative BK viraemia group [median e GFR 60.0(IQR 48.5-74.2) mL /min per 1.73 m^2), positive BK viraemia without BKVN group [median eG FR 55.0(IQR 47.0-76.0) mL /min per 1.73 m^2] and unknown BKV status group [median eG FR 54.0(IQR 43.8-71.0) mL /min per 1.73 m^2]. The incidence and treatment outcomes of BKVN were similar to some centres with BKV surveillance programmes.CONCLUSION Recipients with BVKN have poorer graft function. Although active surveillance for BKV has been shown to be effective in reducing incidence of BKVN, it should be tailored specifically to that transplant centre based on its epidemiology and outcomes of BKVN, particularly in centres with limited resources.AIM To evaluate incidence, risk factors and treatment outcome of BK polyomavirus nephropathy （BKVN） in a cohort of renal transplant recipients in the Auckland region without a formal BK polyomavirus （BKV） surveillance programme.METHODSA cohort of 226 patients who received their renal trans-plants from 2006 to 2012 was retrospectively reviewed.RESULTSSeventy-six recipients （33.6%） had a BK viral load （BKVL） test and 9 patients （3.9%） developed BKVN. Cold ischaemia time （HR = 1.18, 95%CI： 1.04-1.35） was found to be a risk factor for BKVN. Four recipients with BKVN had complete resolution of their BKV infection; 1 recipient had BKVL less than 625 copies/mL; 3 reci-pients had BKVL more than 1000 copies/mL and 1 had graft failure from BKVN. BKVN has a negative impact on graft function [median estimated glomerular filtration rate （eGFR） 22.5 （IQR 18.5-53.0） mL/min per 1.73 m2, P = 0.015）, but no statistically significant difference （ P = 0.374） in renal allograft function was found among negative BK viraemia group [median eGFR 60.0 （IQR 48.5-74.2） mL/min per 1.73 m2）, positive BK viraemia without BKVN group [median eGFR 55.0 （IQR 47.0-76.0） mL/min per 1.73 m2] and unknown BKV status group [median eGFR 54.0 （IQR 43.8-71.0） mL/min per 1.73 m2]. The incidence and treatment outcomes of BKVN were similar to some centres with BKV surveillance programmes.CONCLUSIONRecipients with BVKN have poorer graft function. Although active surveillance for BKV has been shown to be effective in reducing incidence of BKVN, it should be tailored specifically to that transplant centre based on its epidemiology and outcomes of BKVN, particularly in centres with limited resources.

关 键 词：BK virus BK polyomavirus nephropathy Kidney transplantation Screening 

分 类 号：R699.2[医药卫生—泌尿科学]