不同针刺频率对稳定期慢性阻塞性肺疾病患者呼吸功能及免疫状态的影响  

Effects of Different Acupuncture Frequency on Respiratory Function and Immune Status in Patients with Stable Chronic Obstructive Pulmonary Disease

作　　者：陈建飞[1] 罗伟贤[1] 周鸿飞[1] Chen Jianfei;Luo Weixian;Zhou Hongfei(Department of Chinese Medicine,Zhengzhou First People＇s Hospital,Zhengzhou 450004,China)

机构地区：[1]郑州市第一人民医院中医科,郑州450004

出　　处：《世界中医药》2018年第11期2839-2842,共4页World Chinese Medicine

基　　金：河南省卫生厅2015年卫生政策研究课题计划(YWZY201514)

摘　　要：目的:观察不同针刺频率对慢性阻塞性肺疾病(COPD)稳定期患者肺功能的影响,同时比对不同组别患者CD4+、CD4+/CD8+、CD8+以及Th17百分率的变化。方法:选取2015年2月至2016年2月郑州市第一人民医院呼吸内科病房及门诊收治的COPD患者60例纳入本研究,采用随机数字表法分为高频组和低频组,每组30例。2组患者均选取脾俞、胃俞、肺俞、肾俞、太渊、太白、太溪、足三里,在此基础上复感外邪者加合谷穴,痰浊中阻者加丰隆穴。高频组得气后加连接电针仪,频率100 Hz,低频组得气后连接电针仪,频率2 Hz,2组均以耐受为度,1次/d,30 min/次,5次/周,均以10次为1个疗程,共治疗2个疗程。疗程结束后比较2组患者第一秒钟用力呼气容积(FEV1)、用力肺活量(FVC)、及FEV1/FVC比值以及最大通气量(MVV),6 min步行距离(6-MWD)、CD4+、CD8+、CD4+/CD8+及Th17的水平的变化。结果:治疗后低频组肺功能指标,包括FEV1、FVC、FEV1/FVC比值及MVV均明显优于高频组(P均<0. 05);治疗后低频组6-MWD较高频组明显改善(P <0. 05);治疗后2组CD4+、CD8+、CD4+/CD8+均有所升高,CD8+、Th17水平下降,其中低频组优于高频组,差异有统计学意义(P <0. 05)。结论:低频针刺可通过改善患者的免疫功能实现提升肺功能的目的。Objective：To observe the effects of different acupuncture frequency on pulmonary function in patients with chronic ob- structive pulmonary disease（COPD） and to compare the percentage of CD4＋, CD3＋, CD4＋, CD8＋ and Thl7 in different groups. Methods ：Sixty cases in our hospital from February 2015 to February 2016 were included in the study and were randomly divided into high-frequency group and low-frequency group,with 30 cases in each group. Patients of both groups were treated at Pishu（ BL 20）, Weishu （ BL 21 ）, Feishu （ BL 13 ）, Shenshu （ BL 23 ）, Taiyuan （ LU 9 ）, Taibai （ SP 3 ）, Taixi （ KI 3 ）, Zusanli （ ST 36 ）. Addition- ally patients with external pathogen were treated with Hegu（ LI 4 ）, and patients with phlegm-turbidiU obstructing middle-jiao were treated with Fenglong（ST 40）. After needling sensation,high-frequency group was connected with eleetroaeupuneture instrument, with the frequency of 100HZ,low-frequeney group with 2HZ. Two groups were treated under the degree of tolerance,once a day,30 min/tinle ,5 times/week, 10 times as a course of treatment, 2 courses of treatment in total. The Forced Expiratory Volume In 1 s （ FEV1）, forced vital capacity （ FVC ）, FEV1/FVC ratio, maximum ventilatory volume （ MVV ）, 6 min walking distance （ 6-MWD ）, CD4 ＋ , CD8 ＋ and CD4 ＋/CD8 ＋ and Thl7 concentration changes were compared between the 2 groups after treatment. Results ： 1 ） The pulmonary function indexes including FEV- , FVC, FEV-/FVC ratio and MVV in low-frequency group were significantly better than that of high-frequency group （ P 〈 0. 05 ） after treatment ; 2 ） After treatment,6-MWD of low-frequency group was significantly improved（P 〈 0. 05）. 3 ） CD4 ＋ , CD4 ＋/CD8 ＋ of both groups were increased, and CD8 ＋ , Th17 concentrations decreased. The low- frequency group was better than the high-frequency group, and the difference was statistically significant（ P 〈 0. 05 ）. Conclusion： Low-frequency

关 键 词：慢性阻塞性肺疾病 稳定期 针刺 不同频率 免疫功能 临床疗效 肺功能 

分 类 号：R245[医药卫生—针灸推拿学] R563[医药卫生—中医临床基础]