氯化碘催化的喹啉-2-羧酸乙酯类化合物的合成  

Synthesis of Quinoline-2-Carboxylic Acid Ethyl Esters ICl-Catalyzed

作　　者：张宝华[1] 胡永青 刘宏果 张之奎 ZHANG Bao-hua;HU Yong-qing;LIU Hong-guo;Zhang Zhi-kui(School of Chemical Engineering,Shijiazhuang University,Shijiazhuang,Hebei 050035,China;Shijiazhuang Penghai Pharmaceutical Co.,Ltd,Shijiazhuang,Hebei 050060,China)

机构地区：[1]石家庄学院化工学院,河北石家庄050035 [2]石家庄鹏海制药股份有限公司,河北石家庄050600

出　　处：《石家庄学院学报》2018年第6期30-33,共4页Journal of Shijiazhuang University

基　　金：河北省科技支撑项目(18271404D)

摘　　要：以氯化碘(ICl)为催化剂,通过苯胺、乙醛酸乙酯与炔反应制备了喹啉-2-羧酸乙酯类化合物.各种炔、苯胺与乙醛酸乙酯均能顺利反应,产物收率为57%～94%.讨论了底物取代基与产物收率的关系,确证了产物的结构.Catalyzed by ICl, quinoline-2-carboxylic acid ethyl esters are prepared by reacting anilines, ethyl glyoxylates with alkynes. All kinds of alkynes and anilines can react with ethyl glyoxylates smoothly, and the product yields are 57%-94%. The relationship between yields and substituent groups is described. The structure of products is confirmed.

关 键 词：喹啉-2-羧酸乙酯 苯胺 乙醛酸乙酯 炔 氯化碘 

分 类 号：O621.2[理学—有机化学]