子宫内膜异位症术后Gn RH-a联合不同反向添加方案的临床分析  

Clinical Analysis of GnRH-a Combined With Different Reverse Addition Regimen After Preserving Fertility in Endometriosis

作　　者：刘九平[1] 刘进[1] LIU Jiuping;LIU Jin(Department of Obstetrics and Gynecology,Dongtai People＇s Hospital,Dongtai Jiangsu 224200,China)

机构地区：[1]江苏省东台市人民医院妇产科,江苏东台224200

出　　处：《中国继续医学教育》2018年第33期139-141,共3页China Continuing Medical Education

摘　　要：目的探讨子宫内膜异位症保留生育功能术后GnRH-a联合不同反向添加方案的临床效果。方法选取2012年4月—2018年3月在我院接受保留生育功能手术治疗的子宫内膜异位症患者60例作为研究对象,将其随机分为对照组、观察1组、观察2组,每组患者各20例。对照组给予GnRH-a治疗,观察1组在此基础上,联合坤泰胶囊治疗,观察2组在此基础上,联合替勃龙治疗,观察对比三组患者治疗前后雌二醇水平、疼痛评分,并统计分析不良反应发生情况。结果三组患者治疗前雌二醇水平、VAS评分比较,差异无统计学意义(P> 0.05);治疗2个月后,三组上述指标降低,且观察1组、观察2组均低于对照组,差异具有统计学意义(P <0.05),但观察1组、观察2组上述指标比较,差异无统计学意义(P> 0.05);观察组1组、观察2组子宫出血、潮热出汗、烦躁发生率低于对照组,但组间比较,差异无统计学意义(P> 0.05)。结论针对子宫内膜异位症保留生育功能手术治疗患者,术后给予GnRH-a联合不同反向添加方案效果理想,不同方案均具有较高的临床应用价值,且安全性较高。Objective To investigate the clinical effect of GnRH-a combined with different reverse addition regimen after endocidal retention of endometriosis. Methods 60 cases of patients with endometriosis who underwent fertility-preserving surgery in our hospital from April 2012 to March 2018 were selected as the study subjects. They were randomly divided into control group, NO. 1 observation group and NO. 2 observation group, 20 cases in each group. The control group was treated with GnRH-a. On the basis of GnRH-a, NO. 1 observation group combined with the treatment of kuntai capsule. On the basis of GnRH-a, NO. 2 observation group combined with the treatment of tibolone capsule. The levels of estradiol and pain scores before and after treatment were observed and compared among the three groups, and the occurrence of adverse reactions was analyzed. Results There was no significant difference in estradiol level and VAS score between the three groups before treatment （P 〉 0.05）. After 2 months of treatment, the above indexes of the three groups decreased, and NO. 1 observation group and NO. 2 observation group were lower than the control group, the difference was statistically significant （P 〈 0.05）. However, there was no significant difference between NO. 1 observation group and NO. 2 observation group （P 〉 0.05）. The incidence of uterine bleeding, hot flashes, sweating and restlessness in NO. 1 observation group and NO. 2 observation group were lower than those in the control group, but there was no significant difference between the two groups （P 〉 0.05）. Conclusion For patients with endometriosis-preserving fertility surgery, postoperative GnRH-a combined with different reverse addition regimen is ideal. Different regimens have higher clinical value and safety.

关 键 词：子宫内膜异位症 保留生育功能手术 GNRH-A 反向添加方案 亮丙瑞林 替勃龙 

分 类 号：R713[医药卫生—妇产科学]