桃红四物汤加味治疗儿童过敏性紫癜的临床观察  

Clinical Observation on Treatment of Allergic Purpura in Children by Taohong Siwu Decoction

作　　者：谢兰星 谢庆斌[2] XIE Lanxing;XIE Qingbin(Pingxiang City Maternal and Child Health Hospital,Pingxiang 337000,China)

机构地区：[1]江西省萍乡市妇幼保健院,江西萍乡337000 [2]南昌大学第二附属医院

出　　处：《中国医学创新》2018年第32期10-14,共5页Medical Innovation of China

摘　　要：目的:探讨桃红四物汤加味治疗儿童过敏性紫癜的临床效果。方法:选取2014年2月-2018年2月本院收治的儿童过敏性紫癜患儿144例,按照随机数字表法将患儿分为研究组、对照一组和对照二组,各48例。对照一组给予常规治疗,对照二组在常规治疗的基础上联合孟鲁司特咀嚼片治疗,研究组在常规治疗的基础上联合桃红四物汤加味治疗。比较三组患儿的临床疗效及治疗前后炎症因子水平。结果:研究组总有效率明显高于对照一组和对照二组(P<0.05),对照二组总有效率明显高于对照一组(P<0.05)。三组患儿治疗后中医证候积分均明显低于治疗前(P<0.05),其中研究组治疗后中医证候积分明显低于对照一组和对照二组(P<0.05),对照二组治疗后中医证候积分明显低于对照一组(P<0.05)。三组患儿治疗后IL-4、IL-5、IL-6水平均明显低于治疗前(P<0.05),IL-10水平均明显高于治疗前(P<0.05);其中研究组治疗后IL-4、IL-5、IL-6水平均明显低于对照一组和对照二组(P<0.05),IL-10水平明显高于对照一组和对照二组(P<0.05),对照二组治疗后IL-4、IL-5、IL-6水平均明显低于对照一组(P<0.05),IL-10水平明显高于对照一组(P<0.05)。结论:桃红四物汤加味应用于儿童过敏性紫癜的治疗中临床效果显著,能有效调节患儿炎症因子水平,改善其免疫功能,值得临床推广应用。Objective：To investigate the clinical efficacy of Taohong Siwu Decoction in children with allergic purpura.Method： 144 children with allergic purpura in our hospital from February 2014 to February 2018 were selected,they were randomly divided into the study group,the control one group and the control two group,according to the random number table method,48 cases in each group.The control one group was treated with routine treatment,and the control two group was treated with Montelukast on the basis of routine treatment,and the study group combined with the conventional treatment with the combination of the Taohong Siwu Decoction.The clinical efficacy and the level of inflammatory factors before and after treatment were compared among the three groups.Result：The total efficiency of the study group was significantly higher than those of the control one group and control two group（P〈0.05）,and the total efficiency of the control two group was significantly higher than that of the control one group（P〈0.05）.The scores of TCM syndromes in the three groups after treatment were significantly lower than those before treatment（P〈0.05）,the score of TCM syndromes in the study group after treatment were significantly lower than those in the control one group and the control two group（P〈0.05）,the TCM syndrome score after treatment in the control two group was significantly lower than that in the control one group（P〈0.05）.After treatment,the levels of IL-4,IL-5,IL-6 were significantly lower than those before treatment（P〈0.05）,and the levels of IL-10 were significantly higher than those before treatment（P〈0.05）;the levels of IL-4,IL-5,IL-6 in the study group were significantly lower than those in the control one group and the control two group（P〈0.05）,the level of IL-10 was significantly higher than those of control one group and control two group（P〈0.05）,the levels of IL-4,IL-5,IL-6 in control two group were significantly lower than those of control one group（P〈0.05

关 键 词：桃红四物汤 儿童 过敏性紫癜 

分 类 号：R272[医药卫生—中医儿科学]