氨甲环酸联合自体血回输对初次生物型全髋关节置换术后早期康复的影响  

Impact of tranexamic acid combined with autologous blood transfusion on early rehabilitation ofter initial biological type total hip replacement arthroplasty

作　　者：周畅 刘忠 蒋锐中 谭熠 陈校明 ZHO U Chang;LIU Zhong;JIANG Ruizhong;TAN Yi;CHEN Jiaoming(Department of Orthopedics;Department of Anesthesiology,Xiangtan Municipal Central Hospital,Xiangtan,Hunan 411100,China)

机构地区：[1]湘潭市中心医院骨科,湖南411100 [2]湘潭市中心医院麻醉科,湖南411100

出　　处：《现代医药卫生》2018年第22期3434-3436,共3页Journal of Modern Medicine & Health

基　　金：湖南省卫生和计划生育委员会2017年度科研计划课题项目(B2017165)

摘　　要：目的探讨氨甲环酸联合自体血回输对初次生物型全髋关节置换术患者早期康复的影响。方法按照随机数字表法将2016年1月至2018年1月在该院行初次生物型全髋关节置换术的84例患者分为研究组(n=44)与对照组(n=40)。对照组进行自体血回输,研究组在对照组基础上联合静脉滴注氨甲环酸,比较2组凝血及纤溶功能指标、Hariis评分、视觉模拟量表(VAS)评分、术中出血量、回输血量、术后引流量及术后并发症情况。结果研究组术后凝血及纤溶功能指标水平与对照组比较,差异均无统计学意义(P>0.05)。研究组术中出血量、回输血量及术后引流量均少于对照组,差异均有统计学意义(P<0.05)。研究组术后Hari-is评分显著高于对照组,而VAS评分显著低于对照组,差异均有统计学意义(P<0.05)。2组术后并发症发生情况比较,差异无统计学意义(P>0.05)。结论氨甲环酸联合自体血回输不影响初次生物型全髋关节置换术患者的凝血纤溶功能,能明显改善患者的髋关节功能及疼痛情况,减少术后并发症发生,有利于患者早期康复。Objective To investigate the impact of tranexamic acid combined with autologous blood transfusion on early rehabilitation in the patients treated by initial biological type total hip replacement arthroplasty. Methods 84 patients undergoing initial biological type total hip replacement arthroplasty in the hospital from January 2016 to January 2018 were divided into the research group （n=44） and control group （n=40） according to the random number table method.The control group conducted autologous blood transfusion, while the research group was combined with intravenous drip of tranexamic acid on the basis of the control group.The coagulation and fibrinolytic function indexes, Hariis score, visual analogue scale （VAS） score, intraoperative blood loss volume, blood transfusion amount, postoperative drainage amount and postoperative complications were compared between the two groups.Results The levels of postoperative coagulation and fibrinolytic function indexes had no statistically significantly difference between the two groups （P〉0.05）.The intraoperative blood loss volume, amount of blood transfusion and postoperative drainage amount in the research group were less than those in the control group, and the difference were statistically significant （P〈0.05）. The Hariis score in the researchgroup was significantly higher than that in the control group, while the VAS score was significantly lower than that in the control group （P〈0.05）.There was no statistical difference in postoperative complications between the two groups （P〉0.05）. Conclusion Ranexamic acid combined with autologous blood transfusion does not affect the coagulation and fibrinolytic function in the patients with initial biological type total hip replacement arthroplasty, can significantly improves the their hip joint function and pain, reduces the postoperative complications and is conducive to their early recovery.

关 键 词：全髋关节 初次生物型 输血 自体 氨甲环酸 

分 类 号：R687.4[医药卫生—骨科学]