早期高压氧治疗玻尿酸致皮肤缺血的疗效观察  

Effects of hyperbaric oxygen on skin ischemia induced by hyaluronic acid

作　　者：徐晶[1] 谷健[1] 林绍梅 仲蓓[1] 万金娥[1] Xu Jing;Gu Jian;Lin Shaomei;Zhong Pei;Wan Jine.(Hospital Affiliated to Qingdao University,Qingdao 266000,China)

机构地区：[1]青岛大学附属医院,山东省青岛266000

出　　处：《中华航海医学与高气压医学杂志》2018年第5期319-321,共3页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的观察早期高压氧治疗对注射玻尿酸所致皮肤缺血的疗效。方法将注射玻尿酸所致皮肤缺血患者42例依据高压氧治疗情况分为2组：A组，给予常规治疗，部分患者高压氧治疗均于72 h后进行。B组，常规治疗基础上均于注射后72 h内行高压氧治疗。记录2组患者显效时间，并将高压氧开始治疗时间与显效时间行Pearson相关性分析；于注射后第10天比较2组患者的显效率。结果A组平均显效时间为（13.2±2.8）d，B组平均显效时间为（11.0±3.1）d，2组比较差异有统计学意义（P〈0.05）。将高压氧开始治疗时间与显效时间行Pearson相关性分析，高压氧开始治疗时间与显效时间存在正相关（P〈0.05）；于第10天观察，A组显效率为28.57%，B组显效率为53.57%。结论早期应用高压氧治疗对注射玻尿酸所致皮肤缺血的作用是肯定的，且高压氧治疗介入越早显效越快。Objective To observe the therapeutic effects of hyperbaric oxygen （HBO） on skin ischemia induced by hyaluronic acid.Methods Forty-two patients with skin ischemia induced by hyaluronic acid were divided into 2 groups： The patients in group A were given routine treatment, and some patients received HBO therapy 72 hours later, while the patients in group B all received HBO therapy within 72 hours after injection of hyaluronic acid on the basis of routine therapy. Effectual time was recorded and compared between the patients of the 2 groups, and Pearson analysis was performed with respect to HBO implementation time and effectual time. Effectual rates were compared between the 2 groups, 10 days after injection of hyaluronic acid.Results The average effectual time of group A was（13.2±2.8）days, while that of group B was（11.0±3.1）days. Statistical significance could be noted when comparisons were made between them （P〈0.05）. Results of Pearson analysis concerning HBO implementation time and effectual time indicated that there was a positive correlation between HBO implementation time and effectual time （P〈0.05, r〉0）. Observation at day 10 showed that the effectual time of group A was 28.57% and that of group B was 53.57%.Conclusion Therapeutic effects of early HBO therapy on skin ischemia induced by hyaluronic acid injection was positive, and the earlier HBO intervention was made, the earlier the effectual time was.

关 键 词：玻尿酸 高压氧 皮肤缺血 

分 类 号：R459.6[医药卫生—治疗学] R622[医药卫生—临床医学]