Effects of delay in immunological response of HIV infection  

作　　者：Saroj Kumar Sahani Yashi 

机构地区：[1]Department of Mathematics South Asian University, Akbar Bhawan Chankyapuri, New Delhi 110021, India

出　　处：《International Journal of Biomathematics》2018年第6期1-29,共29页生物数学学报（英文版）

摘　　要：In this paper, a human immunodeficiency virus （HIV） infection model with both the types of immune responses, the antibody and the killer cell immune responses has been introduced. The model has been made more logical by including two delays in the acti-vation of both the immune responses, along with the combination drug therapy. The inclusion of both the delayed immune responses provides a greater understanding of long-term dynamics of the disease. The dependence of the stability of the steady states of the model on the reproduction number R0 has been explored through stability theory. Moreover, the global stability analysis of the infection-free steady state and the infected steady state has been proved with respect to R0. The bifurcation analysis of the infected steady state with respect to both delays has been performed. Numerical simulations have been carried out to justify the results proved. This model is capable of explaining the long-term dynamics of HIV infection to a greater extent than that of the existing model as it captures some basic parameters involved in the system such as immunological delay and immune response. Similarly, the model also explains the basic understanding of the disease dynamics as a result of activation of the immune response toward the virus.

关 键 词：HIV humoral immunity immunological delay Hopf bifurcation globalstability. 

分 类 号：S852.4[农业科学—基础兽医学] S858.235.3[农业科学—兽医学]