GRIM-19在银屑病皮损中的表达及维A酸对其影响的研究  

Expression of GRIM-19 in psoriatic lesions and the effect of retinoid acid on it

作　　者：吴娜[1] 郑焱[2] 李昌吉[3] WU Na;ZHENG Yan;LI Chang-ji(Department of Dermatology,Shaanxi Provincial People ＂s Hospital,Xi＇an 710068,China)

机构地区：[1]陕西省人民医院皮肤科,西安710068 [2]西安交通大学第二附属医院皮肤科 [3]酒泉市人民医院皮肤科

出　　处：《实用皮肤病学杂志》2018年第5期259-261,265,共4页Journal of Practical Dermatology

基　　金：国家自然科学基金资助项目(81371732)

摘　　要：目的研究GRIM-19在银屑病皮损中的表达水平及维A酸对其的影响。方法采用免疫组化法检测银屑病皮损中GRIM-19的表达,观察维A酸治疗对其表达的影响。结果正常皮肤组织、银屑病边缘皮损和中间皮损中GRIM-19蛋白的表达强度逐渐减弱,差异有统计学意义(C2=49.18,P <0.05);维A酸治疗前、治疗2周、4周后皮损中GRIM-19表达强度逐渐增强,差异有统计学意义(C2=51.78,P <0.05)。结论 GRIM-19在银屑病皮损中表达下降,维A酸可能通过上调GRIM-19来调控角质形成细胞的增殖凋亡,从而治疗银屑病。Objective To investigate the expression of GRIM-19 in psoriatic lesions and the effect of retinoid acid on it. Methods GRIM-19 expression level in psoriatic lesions and the effect of retinoid acid on it were detected by immunohistochemistry. Results The expression intensity of GRIM-19 protein was gradually weakened successively in normal skin tissues, the marginal region of the psoriatic lesions and the central area of the psoriatic lesions, the different was significant（C^2=49.18, P〈0.05）. Before, 2 weeks after, and 4 weeks after treatment of retinoid acid, GRIM-19 expression in the psoriatic lesions was gradually enhanced（C^2=51.78, P〈0.05）. Conclusion Expression of GRIM-19 in psoriatic lesions was lower than that in normal epidermis. Retinoid acid may inhibit proliferation and induce apoptosis of keratinocytes through up regulating expression of GRIM-19 in epidermis of psoriatic lesions.

关 键 词：银屑病 GRIM-19 维A酸 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]