解毒祛瘀滋阴方治疗轻中度活动性系统性红斑狼疮30例临床观察  

Clinical Observation on Jiedu Quyu Ziyin Prescription for 30 cases of Patients with Mildly-to-moderately Active Systemic Lupus Erythematosus

作　　者：朱永福 黄蔚霞[1] ZHU Yongfu;HUANG Weixia

机构地区：[1]温州市中医院肾病科,浙江温州325000

出　　处：《新中医》2018年第11期150-152,共3页New Chinese Medicine

摘　　要：目的:观察解毒祛瘀滋阴方治疗轻中度活动性系统性红斑狼疮(SLE)的临床疗效。方法:选取60例轻中度活动性SLE患者,随机分为对照组和治疗组各30例。2组均给予相同西医基础治疗方案,治疗组结合解毒祛瘀滋阴方。对比分析2组临床疗效,观察2组治疗前后系统性红斑狼疮疾病活动性指数(SLEDAI)评分及血清中补体C3、C4、抗双链DNA (anti-dsDNA)抗体含量的变化,记录不良反应发生情况。结果:对照组总有效率44.44%,治疗组总有效率78.57%,2组比较,差异有统计学意义(P <0.05)。治疗后,2组SLEDAI评分均较治疗前降低,差异均有统计学意义(P <0.05);治疗组SLEDAI评分低于对照组,差异有统计学意义(P <0.05)。治疗后,2组补体C3、C4含量均较治疗前升高,anti-dsDNA抗体含量均较治疗前降低,差异均有统计学意义(P <0.05);治疗组补体C3、C4含量高于对照组,anti-dsDNA抗体含量低于对照组,差异均有统计学意义(P <0.05)。结论:解毒祛瘀滋阴方能有效改善轻中度活动性SLE患者的临床症状,调节补体C3、C4及抗DS-DNA抗体水平,提高治疗效果。Objective; To observe the clinical effect of Jiedu Quyu Ziyin prescription for mildly-to-moderately active systemic lupus erythematosus （SLE）. Methods. Selected 60 cases of patients with mildly-to-moderately active SLE, and divided them into the control group and the treatment group randomly, 30 cases in each group. The two groups were given the same basic treatment plan of western medicine, while the treatment group was additionally treated with Jiedu Quyu Ziyin prescription. Compared and analyzed the clinical effect in the two groups, observed the changes in the scores of SLE Disease Activity Index（SLEDAI） before and after treatment, and the contents of complement C3, C4 and anti-double stranded DNA （anti-dsDNA） antibody in the serum of the two groups, and recorded the occurrence of adverse reactions. Results= The total effective rate was 44.44% in the control group and 78.57% in the treatment group, the difference being significant（P 〈 0.05）. After treatment, the SLEDAI scores in both groups were decreased when compared with those before treatment, differences being significant（P 〈 0.05）. The SLEDAi score in the treatment group was lower than that in the control group, the difference being significant （P 〈 0.05）. After treatment, the contents of complement C3 and C4 in the two groups were increased when compared with those before treatment, and the contents of anti-dsDNA antibody were decreased, differences being significant （P 〈 0.05）. The contents of complement C3 and C4 in the treatment group were higher than those in the control group, and the content of anti-dsDNA antibody was lower than that in the control group, differences being significant （P 〈 0.05）. Conclusion= Jiedu Quyu Ziyin prescription can effectively improve the clinical symptoms of patients with mildly-to-moderately active SLE, regulate the levels of complement C3, C4 and anti-dsDNA antibody, and improve the therapeutic effect.

关 键 词：系统性红斑狼疮(SLE) 轻中度 活动性 中西医结合疗法 解毒祛瘀滋阴方 系统性红斑狼疮疾病活动性指数(SLEDAI) 补体 抗双链DNA(anti-dsDNA)抗体 

分 类 号：R593.241[医药卫生—内科学]