邓氏暖心胶囊治疗慢性心力衰竭Meta分析  

Meta-analysis on DENG′s Nuanxin Capsules for Chronic Heart Failure

作　　者：何志凌[1] 王侠[1] 姚耿圳[1] 吴焕林[1] HE Zhiling;WANG Xia;YAO Gengzhen;WU Huanlin

机构地区：[1]广州中医药大学第二临床医学院,广东广州510515

出　　处：《新中医》2018年第8期25-28,共4页New Chinese Medicine

基　　金：广东省科学技术厅科技计划项目(20140212)

摘　　要：目的:为提高名老中医学术经验循证医学证据级别,利用文献数据分析方法研究国医大师邓铁涛教授暖心胶囊治疗慢性心力衰竭(Ch ron ic h e a rt fa ilure,CHF)的疗效。方法:检索2017年7月前发表的邓氏暖心胶囊治疗CHF的中英文随机对照试验文献,依照纳入与排除标准入选文献后,利用Coc h ra n e偏倚风险工具评估纳入文献,采用Re v Ma n 5.3软件进行Me ta分析。结果:共纳入6项临床研究,588例研究对象,其中对照组29 3例,暖心胶囊组29 5例,研究质量评价理想。Me ta分析提示暖心胶囊联合常规治疗能改善心力衰竭患者的心功能评级(P=0.000 4);同时能改善射血分数保留的左心室射血分数(LVE F),但不同的心脏彩超测量结果可能干扰E F疗效结局的一致性。结论:暖心胶囊治疗CHF具有良好的临床效益,值得进一步推广;且可以在目前的研究基础上,基于个体病例进行Me ta分析以进一步提升其循证证据级别。Objective：In order to promote the grade of evidence of evidence-based medicine regarding academic experience of the prestigious Chinese medicine practitioners,the method of data analysis on literature will be used to study the clinical effect of Nuanxin capsules of the master of national Chinese medical science Professor DENG Tietao for chronic heart failure（CHF）. Methods：Retrieved the literature on randomized controlled trials of DENG＇s Nuanxin capsules for CHF in Chinese or English before July 2017. After selecting literature according to the inclusive and exclusive criteria, used Cochrane risk of bias tool to include the literature, and adopted the software Rev Man5.3 to do the meta-analysis. Results： Totally included 6 clinical researches and 588 cases of research objects,among which there were 293 cases in the control group and 295 cases in the Nuanxin capsules group. The quality of researches was optimal. The meta-analysis indicated that Nuanxin capsules combined with the routine treatment could improve the grading of cardiac function of patients with heart failure（P= 0.000 4）; meanwhile, it could improve the left ventricular ejection fraction with preserved ejection fraction（LVEF）,but the different ultrasonic cardiogram results might disturb the consistency of clinical outcomes of EF. Conclusion：Nuanxin capsules has good clinical effect in treating CHF,which is worthy of further promotion;and meta-analysis can be conducted based on the individual cases to further promote the grade of evidence of evidence-based medicine on the basis of the current researches.

关 键 词：暖心胶囊 慢性心力衰竭(CHF) META分析 

分 类 号：R541.6[医药卫生—心血管疾病]