基于数据挖掘的唐宋前后中风病古方用药规律分析  

Analysis on Administration Rule of Ancient Prescriptions for Stroke Before and After Tang and Song Dynasties Based on Data Mining

作　　者：徐敏[1] 谢蓉[2] 张现伟[2] 连新福[2] XU Min;XIE Rong;ZHANG Xianwei;LIAN Xinfu

机构地区：[1]广州中医药大学,广东广州510006 [2]广东省中医院珠海医院,广东珠海519000

出　　处：《新中医》2018年第8期29-32,共4页New Chinese Medicine

基　　金：2015年度中国中医药行业科研专项项目(20150003-8)

摘　　要：目的:探讨唐宋前后中风病古方的用药规律。方法:收集《中华医典·方书类》中符合纳入标准的方剂,用E xc el软件建立数据库,采用SPSS23.0对数据进行频数分析及聚类分析。结果:唐宋以前共收录治疗中风的方剂(包括宋)516首,唐宋以后6 9 8首,涉及中药29 3种,且唐宋前后使用频率较高的前10味中药均包括防风、肉桂、麻黄、川芎、附子、当归、独活、甘草、天麻、人参,药类频次分析表明唐宋前后使用频次最高的均为解表类药物,分别占使用频次的18.8%、17.5%,其次为补益类、祛风湿类、熄风类、温里类、理血类等;聚类分析唐宋前共获得8个核心药物组合,唐宋后14个,其共同核心组合为全蝎和僵蚕、麻黄和川芎。结论:不论唐宋前后,解表药为治疗中风最常用药,其中防风为治疗中风的第一要药,而外感风邪在唐宋前后中风病发病过程中均具有重要作用。Objective： To explore the administration rule of ancient prescriptions for stroke before and after Tang and Song Dynasties. Methods： Collected the prescriptions in Encyclopaedia of Traditional Chinese Medicine-Chinese Medical Book Section that were in accordance with the including criteria. Set up a database via Excel software and carried out the frequency analysis and cluster analysis of the data via SPSS23.0. Results： There were 516 prescriptions for stroke before Tang and Song Dynasties（including Song Dynasty）, and 698 prescriptions after Tang and Song Dynasties, involving 293 kinds of Chinese medicine in total. Before and after Tang and Song Dynasties,the top ten Chinese medicine with high frequency were Radix Saposhnikoviae,Cortex Cinnamomi,Herba Ephedrae,Rhizoma Chuanxiong,Radix Aconiti Lateralis Praeparata,Radix Angelicae Sinensis,Radix Angelicae Pubescentis,Radix et Rhizoma Glycyrrhizae,Rhizoma Gastrodiae and Radix et Rhizoma Ginseng. The frequency analysis of the categorization of Chinese medicine showed that the highest frequency of usage before and after Tang and Song Dynasties was exterior-releasing medicine,accounting for 18.8% and 17.5% respectively, followed by tonifying and replenishing medicine, wind-damp dispelling medicine,wind-extinguish medicine,interior-warming medicine and blood-rectifying medicine. The cluster analysis showed that there were eight core medical combinations before Tang and Song Dynasties, and fourteen after Tang and Song Dynasties; the common core combination were Scorpio and Bombyx Batryticatus,Herba Ephedrae and Rhizoma Chuanxiong. Conclusion：No matter before or after Tang and Song Dynasties, exterior-releasing medicine is the most commonly used for stroke with Radix Saposhnikoviae as the key medicine,and the external contraction of wind evil plays an important role in the pathogenesis of stroke before and after Tang and Song Dynasties.

关 键 词：中风病 方剂 用药规律 数据挖掘 

分 类 号：R255.2[医药卫生—中医内科学]