ICP-AES法测定麻杏石甘汤杏仁剂量变化对微量元素的影响  

Effect of different amount of almond in Maxing Shigan decoction on trace element content by ICP-AES

作　　者：张五萍[1] 寇光[1] 饶毅[2] 魏惠珍[2] 伍锡栋 ZHANG Wuping;KOU Guang;RAO Yi;WEI Huizhen;WU Xidong(Department of Pharmacy,Jiangxi Provincal People＇s Hospital,Nanchang 330006,China;National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine;S.Jiangxi Testing Center of Medical Instrument)

机构地区：[1]江西省人民医院药学部,南昌330006 [2]中药固体制剂制造技术国家工程研究中心 [3]江西省医疗器械检测中心

出　　处：《山西医科大学学报》2018年第11期1319-1323,共5页Journal of Shanxi Medical University

基　　金：江西省卫生计生委中医药科研计划课题(2017A315)

摘　　要：目的观察麻杏石甘汤中杏仁剂量变化对Ca、Mg、Fe、Mn和Cu微量元素溶出的影响,为随证施量提供理论参考。方法改变麻杏石甘汤中杏仁剂量,固定其他药材(麻黄、石膏、甘草)剂量,利用电感耦合高频等离子体原子发射光谱(ICPAES)测定各水煎液中5种微量元素的溶出总量。结果元素Ca、Mg、Fe、Mn、Cu的回收率分别100. 67%,98. 17%,99. 84%,98. 83%,97. 72%;精密度试验结果分别为0. 91%,0. 97%,1. 04%,1. 09%,1. 07%。Ca的溶出总量与杏仁剂量及加水量均呈现正相关(r均为0. 992,P均为0. 000)。Mg、Fe、Mn的溶出总量与杏仁剂量呈现负相关(r分别为0. 957,0. 944,0. 944,P均为0. 000)。Cu与杏仁剂量的相关性不显著(r=0. 489,P=0. 229)。结论 ICP-AES法具有良好的准确度和精密度。Ca的溶出总量受加水量影响,Mg、Fe、Mn的溶出总量随着杏仁剂量增加而减少,Cu的溶出总量与杏仁剂量变化无关。Objective To observe the effect of different almond doses in Maxing Shigan decoction on the contents of Ca, Mg, Fe, Mn and Cu so as to provide a theoretical basis for individual treatment. Methods Based on the fixed dose of other herbs（ephedra, gypsum, liquorice） , the contents of Ca, Mg, Fe, Mn and Cu were determined in Macing Shigan decoction with different almond doses by ICP-AES. Results The recoveries of the elements Ca, Mg, Fe, Mn and Cu were 100. 67% , 98.17% , 99. 84% , 98.83% and 97. 72% , respectively. The preeisions of the elements Ca, Mg, Fe, Mn and Cu were 0. 91% , 0. 97% , 1.04% , 1.09% and 1.07% , respectively. The total dissolved amount of Ca was positively correlated with the dose of almond and the amount of water added（ both r = 0. 992,P = 0. 000）. The total dissolved amounts of Mg, Fe, Mn were negatively correlated with the dose of almond （ r = 0. 957, 0. 944, 0. 944, respectively,P = 0. 000）. The correlation between Cu and the dose of almond showed no significance （ r = 0. 489,P = 0. 229）. Co^elusion ICP-AES method is accurate and precise. The total dissolved amount of Ca is affected by the amount of water added. The total dissolved amounts of Mg, Fe, and Mn decrease as the dose of almond increases. The total dissolved amount of Cu is not correlated with almond dose.

关 键 词：麻杏石甘汤 杏仁 微量元素 溶出 

分 类 号：R927.1[医药卫生—药学]