大气细颗粒物导致呼吸系统疾病及相关生物机制的研究进展  

Recent progress on respiratory diseases induced by atmospheric fine particulate matters and related biological mechanisms

作　　者：任泉仲 徐立宁 徐明 刘思金[1,2] Quanzhong Ren;Lining Xu;Ming Xu;Sijin Liu(State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院生态环境研究中心环境化学与生态毒理学国家重点实验室,北京100085 [2]中国科学院大学,北京100049

出　　处：《中国科学：化学》2018年第10期1260-1268,共9页SCIENTIA SINICA Chimica

基　　金：中国科学院战略性先导科技专项(编号:XDB14000000);国家重点基础研究发展计划(编号:2014CB932000;2015CB931900)资助项目

摘　　要：大气细颗粒物(PM_(2.5))是导致空气污染和雾霾的重要原因之一. PM_(2.5)组成复杂,常吸附并携带重金属、持久性有机污染物和病原微生物等有毒有害物质,通过呼吸暴露对人体健康产生危害.目前,有诸多流行病学研究表明, PM_(2.5)暴露与呼吸系统疾病的发生存在关联.本文简要介绍该领域的现状和相关研究进展,并探讨潜在的生物机制和存在的科学问题,最后对这个领域将来的研究重点进行展望.Atmospheric fine particulate matter （PM2.5） is one of the most important causes of air pollution and smog. The composition of PM2.5 is complicated with many hazardous substances such as heavy metals, persistent organic pollutants, and pathogenic microorganisms, which are pathogenic risks to human being through respiratory exposure. In recent years, many epidemiological studies have shown that there is a correlation between PM2.5 exposure and the occurrence of respiratory diseases. Here, we briefly reviewed the current status and recent progress in this research field, discussed the underlying biological mechanisms and existing problems, and outlooked the future focus in this research field.

关 键 词：细颗粒物 呼吸暴露 呼吸系统疾病 致病风险 生物机制 

分 类 号：X513[环境科学与工程—环境工程]