原发性甲状旁腺功能亢进症神经心理改变及可能机制  

Neuropsychological changes and possible mechanisms of primary hyperparathyroidism

作　　者：朱旻婷 刘建民[1] ZHU Min-ting;LIU Jian-min(Department of Endocrine and Metabolic Diseases,Shanghai Institute of Endocrine and Metabolic Diseases,Shanghai Clinical Center for Endocrine and Metabolic Diseases,Ruifin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院内分泌代谢科上海市内分泌代谢病研究所上海市内分泌代谢病临床医学中心,上海200025

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2018年第5期503-508,共6页Chinese Journal Of Osteoporosis And Bone Mineral Research

摘　　要：原发性甲状旁腺功能亢进症患者存在神经系统相关症状,会出现包括记忆力减退、视觉空间能力下降在内的认知功能障碍,焦虑、抑郁情绪和生活质量下降等精神心理学改变,甲状旁腺切除术治疗后能部分改善。甲状旁腺素、血钙、维生素D、血管因素及骨钙素等因子可能在其中发挥作用。研究原发性甲状旁腺功能亢进症和神经系统的关系有助于加深对疾病的认知,并为改进治疗方案提供新的依据。Primary hyperparathyroidism may have nervous system-related symptoms, including cognitive impairments like memory loss, reduced visual spatial capacity, anxiety, depression, and reduced quality of life. Partial improvement has been observed after parathyroidectomy. Parathyroid hormone, blood calcium, vitamin D, vascular factors, osteocalcin, and other factors may play an important role in the mechanism. Studying the relationship between primary hyperparathyroidism and the nervous system can help deepen the understanding of the disease and improve the treatment.

关 键 词：原发性甲状旁腺功能亢进症 神经系统 甲状旁腺切除术 

分 类 号：R582[医药卫生—内分泌]