银杏叶片提取物联合丁苯酞对轻中度阿尔茨海默病患者血清生化指标的影响  

Effect of Ginkgo biloba extract combined with butylphthalide on serum biochemical indexes of patients with mild to moderate Alzheimer's disease

作　　者：聂晓枫[1,2] NIE Xiao-feng(Clinical Teaching and Research Office of Weinan Vocational ＆ Technical College,Weinan 714000,China;Department of Neurology,Weinan Central Hospital in Shaanxi Province,Weinan 714000,China)

机构地区：[1]渭南职业技术学院临床教研室 [2]陕西省渭南市中心医院神经内科,陕西渭南714000

出　　处：《海南医学院学报》2018年第21期1889-1892,1897,共5页Journal of Hainan Medical University

基　　金：陕西省社会发展科技攻关项目(2017SF-032)~~

摘　　要：目的:研究银杏叶片提取物联合丁苯酞对轻中度阿尔茨海默病患者血清生化指标的影响。方法:选择2015年3月~2017年12月期间在渭南市中心医院首次诊断为轻中度阿尔茨海默病的患者作为研究对象,并随机分为两组,观察组接受盐酸多奈哌齐片+银杏叶片提取物片+丁苯酞软胶囊治疗,对照组接受盐酸多奈哌齐片治疗。治疗前及治疗后3个月时,测定血清中代谢产物、细胞因子、氧化应激介质等生化指标的含量。结果:治疗后3个月时,两组患者血清中Hcy、IL-1β、TNF-α、HMGB1、MCP-1、MDA、Tau的含量均显著低于治疗前,UA、VitB12、FA、VEGF、BDNF、GPX3、CAT、SOD的含量均显著高于治疗前,且观察组患者治疗后血清Hcy、IL-1β、TNF-α、HMGB1、MCP-1、MDA、Tau含量均显著低于对照组,UA、VitB12、FA、VEGF、BDNF、GPX3、CAT、SOD含量均显著高于对照组,差异均有统计学意义(P<0.05)。结论:银杏叶片提取物联合丁苯酞治疗轻中度阿尔茨海默病能够显著改善物质代谢并减轻炎症应激反应。Objective： To study the effect of Ginkgo biloba extract combined with butylphthalide on serum biochemical indexes of patients with mild to moderate Alzheimer＇s disease. Methods： The patients who were diagnosed with mild to moderate Alzheimer＇s disease for the first time in Weinan Central Hospital between March 2015 and December 2017 were selected as the research subjects and randomly divided into two groups, observation group received donepezil hydrochloride tablets ＋ Ginkgo biloba extract tablets ＋ butylphthalide soft capsules treatment, and control group received donepezil hydrochloride tablets treatment. The serum levels of metabolites, cytokines, and oxidative stress mediators were measured before treatment and 3 months after treatment. Results： Three months after treatment, serum Hcy, IL-1β, TNF-α, HMGB1, MCP-1, MDA and Tau levels of patients of both groups were significantly lower than those before treatment whereas UA, VitB12, FA, VEGF, BDNF, GPX3, CAT and SOD levels were significantly higher than those before treatment, and serum Hcy, IL-1β, TNF-α, HMGB1, MCP-1, MDA and Tau levels of observation group after treatment were significantly lower than those of control group whereas UA, VitB12, FA, VEGF, BDNF, GPX3, CAT and SOD levels were significantly higher than those of control group. Conclusion： Ginkgo biloba extract combined with butylphthalide treatment can significantly improve the substance metabolism and reduce the inflammatory stress response of mild to moderate Alzheimer＇s disease.

关 键 词：阿尔茨海默病 银杏叶片提取物 丁苯酞 炎症反应 氧化应激 

分 类 号：R749.16[医药卫生—神经病学与精神病学]