慢性肾小球肾炎患者肾功能损害、细胞外基质调节作用、肾脏纤维化及炎症程度的变化分析  

Changes of renal function impairment,extracellular matrix regulation,renal fibrosis and inflammation in patients with chronic glomerulonephritis

作　　者：胡湘尘 张月 刘明全[3] HU Xiang-chen;ZHANG Yue;LIU Ming-quan(Clinical Laboratory,the Second people＇s Hospital of Liangshan Yi Autonomous Prefecture,Xichang 615000,China;Department of Renal Medicine,the First people＇s Hospital of Liangshan Yi Autonomous Prefecture,Xichang 615000,China;Clinical Laboratory,the First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,China)

机构地区：[1]凉山彝族自治州第二人民医院检验科,四川西昌615000 [2]凉山彝族自治州第一人民医院肾内科,四川西昌615000 [3]成都医学院第一附属医院检验科,四川成都610500

出　　处：《海南医学院学报》2018年第21期1902-1905,共4页Journal of Hainan Medical University

基　　金：四川省技术创新资助项目(2015CD01281)~~

摘　　要：目的:探讨慢性肾小球肾炎患者肾功能损害、细胞外基质调节作用、肾脏纤维化及炎症程度水平变化及临床意义。方法:选择我院于2016年5月至2018年2月间收治的50例慢性肾小球肾炎患者作为观察组,选取50例同期体检健康者作为对照组,观察比较两组肾功能损害[包括尿酸(UA)、视黄醇结合蛋白(RBP)及Ⅳ型胶原(Col-Ⅳ)]、细胞外基质调节作用[包括金属蛋白酶组织抑制剂-1(TIMP-1)及基质金属蛋白酶-9(MMP-9)]、肾脏纤维化[包括转化生长因子-β1(TGF-β1)、层黏连蛋白(LN)及透明质酸(HA)]及炎症程度[包括白细胞诱素-1(Lkn-1)及肿瘤坏死因子-α(TNF-α)]相关指标的表达水平并进行分析。结果:两组研究对象在肾功能损害、细胞外基质调节作用、肾脏纤维化及炎症程度方面变化明显,相较于对照组健康体检者,观察组患者UA[(352.49±26.57)μmol/L]、RBP[(98.75±26.91)mg/L]、Col-Ⅳ[(224.77±72.32)ng/L]、TIMP-1[(145.79±49.67)ng/mL]、MMP-9[(177.71±52.35)ng/mL]、TGF-β1[(15.23±7.61)ng/mL]、LN[(153.82±23.01)μg/L]、HA[(366.80±77.98)μg/L]、Lkn-1[(82.71±20.64)pmol/L]及TNF-α[(138.01±45.26)pg/mL]水平均显著升高,差异均有统计学意义(P<0.05)。结论:慢性肾小球肾炎患者出现肾功能损害及细胞外基质调节作用的异常,且肾脏纤维化严重,机体处于较高的炎症水平,临床中应加强相关指标的检测,以期为该病的早期诊断及治疗提供依据。Objective： To investigate the changes and clinical significance of renal function impairment, extracellular matrix regulation, renal fibrosis and inflammation in patients with chronic glomerulonephritis. Methods： A total of 50 patients with chronic glomerulonephritis admitted to our hospital from May 2016 to February 2018 were selected as observation group and 50 healthy peoplewho had physical examination during the same period as control group.The expression levels and related inflammatory markers of renal dysfunction [Uric acid （UA）, retinol binding protein （RBP） and type Ⅳ collagen （Col-Ⅳ）], extracellular matrix modulation [tissue inhibitor of metalloproteinase -1 （TIMP-1） and matrix metalloproteinase -9 （MMP-9）], renal fibrosis [transforming growth factor β1 （TGF-β1）, laminin （LN） and hyaluronic acid （HA）.] and degree of inflammation [including leukocyte stimulating hormone-1 （Lkn-1） and tumor necrosis factor-α （TNF-α）] were observed and compared between the two groups. Results： The changes of renal function impairment, extracellular matrix regulation, renal fibrosis and inflammation were significant in both groups.Compared with the control group, UA, RBP, Col-Ⅳ,TIMP-1, MMP-9, TGF-β1, LN, HA, Lkn-1and TNF-αlevels were significantly increased （ P 〈0.05）. Conclusions： Chronic glomerulonephritis patients are associated with renal dysfunction, abnormal regulation of extracellular matrix, severe renal fibrosis, and a higher level of inflammation, thus clinical indicators should be strengthened to detect the early diagnosis of the disease and treatment basis.

关 键 词：慢性肾小球肾炎 肾功能 细胞外基质调节作用 肾脏纤维化 

分 类 号：R692.31[医药卫生—泌尿科学]