中西医结合对急性缺血性脑卒中患者作用的随机、双盲、对照研究  

Randomized,double-blind,controlled study on the effect of integrated traditional Chinese and Western Medicine on patients with acute ischemic stroke

作　　者：程一升 吴凌康[2] CHENG Yi-sheng;WU Ling-kang(Department of Neurology,Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine,Wenzhou,Zhejiang 315033,China)

机构地区：[1]温州市中西医结合医院神经内科,浙江温州325000 [2]浙江省新华医院治未病中心,浙江杭州310000

出　　处：《中华全科医学》2018年第11期1901-1905,共5页Chinese Journal of General Practice

基　　金：2017年浙江省中医药科学研究基金项目(2017ZH065)

摘　　要：目的观察灯盏生脉胶囊与替罗非班联合应用对缺血性脑卒中患者的疗效,为中西医结合治疗缺血性脑卒中提供参考。方法选择2017年1月—2018年4月温州市中西医结合医院收治的112例急性缺血性脑卒中患者,将其随机分配到对照组或观察组,每组各56例,对照组给予常规和对症治疗,并给予替罗非班静脉滴注和灯盏生脉安慰剂胶囊口服,观察组治疗方法将对照组的安慰剂改为灯盏生脉胶囊。治疗前和治疗后分别采用美国国立卫生研究院卒中量表(NIHSS)、改良Rankin评分量表(MRS)及Barthel量表(BS)对患者进行评分,同时检测凝血功能指标,记录可能的药物不良反应,采用SPSS 22. 0统计软件进行统计分析。结果 2组的一般临床资料差异无统计学意义(均P> 0. 05),治疗后,观察组的NIHSS得分、MRS得分低于对照组(均P <0. 05),BS得分高于对照组(P <0. 05),治疗后,观察组的活化部分凝血活酶时间(APTT)及凝血国际标准化比值(INR)高于对照组(均P <0. 05),2组均未出现严重不良反应。结论灯盏生脉胶囊与替罗非班联合应用对促进缺血性脑卒中患者的神经功能恢复,改善凝血功能指标有良好作用,药物不良反应较少。Objective To observe the effect of Dengzhan Shengmai capsule combined with tirofiban on ischemic stroke, and to provide reference for the combination of traditional Chinese and Western medicine in the treatment of isehemic stroke. Methods From January, 2017 to April, 2018, 112 patients with acute ischemic stroke were randomly assigned to the control group or the observation group, with 56 cases in each group. The control group was given routine and symptomatic treatment, tirofiban intravenous infusion and Dengzhan Shengmai placebo capsule were given, too. The treatment method of the observation group changed the placebo to Dengzhan Shengmai capsule. Before and after treatment, the two groups were measured by the National Institutes of Health Stroke Scale （NIHSS）, the Modified Rankin scale （MRS） and the Barthel scale （BS） to the patients. At the same time, the coagulation function indexes were detected, the possible adverse drug reactions were recorded, and the SPSS 22.0 statistical software was used for statistical analysis. Results There was no statistical difference in general clinical data between the two groups （ P 〉 0.05 ）. After treatment, the score of NIHSS and MRS in the observation group were lower than that of the control group （ P 〈 0.05）, and the score of BS was higher than that of the control group （ P 〈 0.05 ）. After the treatment, the activated partial thromboplastin time （APTI＇） and the international standardized ratio （INR） in the observation group were higher than those of the control group （P 〈 0.05）. No serious adverse reactions were found in the two groups. Conclusion The combination of Dengzhan Shengmai capsule combined with tirofiban can play a good role in promoting the recovery of nerve function and improving the index of coagulation function in the patients with ischemic stroke, and the adverse drug reaction is less.

关 键 词：灯盏生脉胶囊 缺血性脑卒中 中西医结合 

分 类 号：R286[医药卫生—中药学] R743.3[医药卫生—中医学]