改良手法复位与盐酸倍他司汀对BPPV患者临床治疗效果分析  

Effect of Modified Manual Reduction and Betahistine Hydrochloride on Clinical Treatment of Patients with BPPV

作　　者：王志平 张义[1] 白秀清[1] 许尧生[1] 朱宁 Wang Zhipin;Zhang Yi;Bai Xiuqing;Xu Yaosheng;Zhu Ning(Harrison International Peace Hospital,Hengshui,05300)

机构地区：[1]河北省衡水市哈励逊国际和平医院

出　　处：《基因组学与应用生物学》2018年第11期5037-5042,共6页Genomics and Applied Biology

基　　金：衡水市科技计划项目(2016014100Z)资助

摘　　要：为分析改良手法复位与盐酸倍他司汀对良性阵发性位置性眩晕（BPPV）患者血清γ球蛋白水平变化及临床治疗效果的影响，本研究选择于2014年6月至2017年1月在我院收治的136例BPPV患者作为实验对象。实验分成两组，对照组采用传统改良手法复位治疗，观察组在改良手法复位治疗的基础上辅以盐酸倍他司汀治疗，分析两组患者治疗效果。结果表明，观察组患者起效时间快于对照组，平均复位次数少于对照组（p〈0.05）。通过治疗后，两种方法兼施的患者血清γ球蛋白水平以及VAS评分均低于对照组（p〈0.05）。治疗1周后，观察组患者DHI症状评分、心理评分、社会功能评分、总分减分值均高于对照组（p〈0.05）。4周的短期治疗两组患者DHI各项评分减分值无统计学差异（p〉0．05）。在随后的8周、12周和24周时观察组复发率均少于对照组，但组间比较无统计学差异（p〉0.05）。本研究表明改良手法复位联合盐酸倍他司汀治疗BPPV起效时间快，可有效减轻头痛，降低血清γ球蛋白水平，提高患者生活质量。To analyze the effect of modified manual reduction and betahistine hydrochloride on serum gamma globulin levels and clinical outcomes in patients with benign paroxysmal positional vertigo （BPPV）, the 136 patients with BPPV in our hospital from Jun. 2014 to Jan. 2017 were selected as research objectives and divided into two groups. The control group was treated with traditional modified manual reduction, and the observation group was treated with modified manual reduction and supplemented with betahistine hydrochloride. The therapeutic effects of the two groups were analyzed. The results showed that the onset time of the observation group was faster than that of the control group, and the average number of reductions was lower than that of the control group （p〈0.05）. After treatment, the serum gamma globulin levels and VAS scores of the two methods were lower than those of the control group （/9〈0.05）. After 1 week of treatment, the DHI symptom score, psychological score, social function score, and total score reduction score of the observation group were higher than those of the control group （p 〈0.05）. There was no significant difference in DHI scores between the two groups in the short-term treatment of 4 weeks （p〉0.05）. At the following 8 weeks, 12 weeks and 24 weeks, the recurrence rate of the observation group was lower than that oft he control group, but there was no significant difference between the groups （p 〉0.05）. This study showed that improved manipulative reduction combined with betahistine hydrochloride for the rapid onset of BPPV can effectively reduce headache, reduce serum gamma globulin levels, and improve patients＇ quality of life.

关 键 词：手法复位 盐酸倍他司汀 良性阵发性位置性眩晕 血清γ球蛋白 

分 类 号：R764[医药卫生—耳鼻咽喉科]