初探输血传播病毒与类风湿关节炎患者的关系  

A Preliminary Study on the Relationship between Transfusion Transmitted Virus and Rheumatoid Arthritis

作　　者：和芳[1] 俞娟[1] 晋松[1] 梅坚[1] 范宏涛[1] 李芹[1] 林俊[1] He Fang;Yu Juan;Jin Song;Mei Jian;Fan Hongtao;Li Qin;Lin Jun(The First People＇s Hospital of Yunnan Province,Kunming,65003)

机构地区：[1]云南省第一人民医院

出　　处：《基因组学与应用生物学》2018年第11期5193-5200,共8页Genomics and Applied Biology

基　　金：云南省第一人民医院资助

摘　　要：输血传播病毒（transfusion transmitted virus，TTV）是一种新的DNA病毒，通常由输血途径传播，其基因组变异率与RNA病毒相似，但是很难预测其致病力是否会朝着增强的方向发展。本研究探讨了TTV病毒与类风湿关节炎患者之间的关系。研究发现类风湿性关节炎患者存在TTV感染，其感染率显著高于正常人群，性别上无明显差异，不存在某种特定基因型感染，初步明确了类风湿性关节炎患者和正常人群对TTV的感染率，并进一步探讨了该病毒基因分型对类风湿性关节炎患者和正常人群两组人群的影响。Transfusion transmitted virus （TTV） is a new DNA virus, usually transmitted by blood transfusion, whose genome mutation rate is no less than that of the RNA virus. It is difficult to predict whether its pathogenicity will develop in the direction of enhancement. This study investigated the coexistence of TTV virus with rheumatoid arthritis and other diseases. The study found that patients with rheumatoid arthritis TTV infection, the infection rate was significantly higher than normal population, there was no significant difference in gender, and they also didn＇t have a particular genotype of infection.The infection rate of TTV in patients with rheumatoid arthritis and normal population was preliminarily defined, and to further discuss the effect of the virus gene type of rheumatoid arthritis arthritis patients and normal subjects in the two groups.

关 键 词：类风湿性关节炎 输血传播病毒 正常人群 感染率 基因分型 

分 类 号：R593.22[医药卫生—内科学]