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作 者:郑福增[1] 范围[1] 孟庆良[1] 周子朋[1] 马晨[2] 杨少祥 李红旗 马梦洋 ZHENG Fu-zeng;FAN Wei;MENG Qing-liang;ZHOU Zi-peng;MA Chen;YANG Shao-xiang;LI Hong-qi;MA Meng-yang(The Second Affiliated Hospital of Henan University of TCM,Henan Province TCM Hospital,Zhengzhou,Henan,China,450002;Henan University of TCM,Zhengzhou,Henan,China,450046)
机构地区:[1]河南中医药大学第二附属医院河南省中医院,河南郑州450002 [2]河南中医药大学,河南郑州450046
出 处:《河南中医》2018年第10期1594-1598,共5页Henan Traditional Chinese Medicine
基 金:河南省中医药科学研究专项课题项目(编号:2015ZY02021)
摘 要:目的:观察红花注射液对活动期类风湿关节炎(Rheumatoid Arthritis,RA)的临床疗效及其对纤维蛋白原(Fibrinogen,FIB)及D-二聚体(D-dimer,DD)的影响。方法:将120例活动期RA患者随机分为治疗组和对照组,每组各60例。对照组单纯常规西药疗法,治疗组在对照组的基础上静脉滴注红花注射液。比较两组患者的临床疗效及治疗前后DAS28评分情况;检测两组患者治疗前后血沉(erythrocyte sedimentation rate,ESR)和C反应蛋白(C reactive protein,CRP)、白细胞介素-1(interleukin-1,IL-1)、DD及FIB水平。结果:对照组有效率为73. 2%,治疗组有效率为89. 1%,两组患者临床疗效比较,差异具有统计学意义(P <0. 05)。两组患者治疗后DAS28评分低于治疗前,且治疗组低于对照组,差异具有统计学意义(P <0. 05)。两组患者治疗后ESR、CRP、IL-1、DD及FIB水平低于治疗前,且治疗组低于对照组,差异具有统计学意义(P <0. 05)。结论:红花注射液能有效改善活动期RA患者临床症状及炎症指标,同时可降低患者DD、FIB水平。Objective: To observe the clinical curative effect of Safflower Injection on active rheumatoid arthritis(RA) and the influence on fibrinogen and D-dimer. Methods: One hundred patients with active RA were randomly divided into the treatment group and the control group,with 60 cases in each group. The ones in the control group were given conventional Western medicine only,while the ones in the treatment group were injected with Safflower Injection on the basis of the control group. The clinical efficacy and DAS28 score before and after the treatment were compared between the two groups. The levels of erythrocyte sedimentation rate(ESR),C reactive protein(CRP),interleukin-1(IL-1),D-dimer(DD),Fibrinogen,FIB before and after the treatment in the two groups were tested. Results: The effective rate of the control group was 73. 2%,and that of the treatment group was 89. 1%. The difference was statistically significant(P〈0. 05). The DAS28 score of the two groups after the treatment was lower than that before the treatment,and the treatment group was lower than that of the control group,the difference was statistically significant(P〈0. 05). After the treatment,the levels of ESR,CRP,IL-1,DD and FIB in the two groups were lower than those in the control group,and the differences were statistically significant(P〈0. 05). Conclusion: Safflower Injection can effectively improve the clinical symptoms and inflammatory indicators of RA patients in active phase,and reduce the levels of D-dimer and fibrinogen.
关 键 词:类风湿关节炎 红花注射液 D-二聚体 纤维蛋白原
分 类 号:R259.932.2[医药卫生—中西医结合]
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