四磨饮子治疗老年2型糖尿病肾病  

Si Mo Yin Zi in Treatment Of Type 2 Diabetic Nephropathy with Elderly Patients

作　　者：胡伟 张洪雷[2] HU Wei;ZHANG Honglei(TCM Hospital of Taierzhuang District of Zaozhuang city,Zaozhuang Shandong China 277400;Chongqing Traditional Chinese Medicine Hospital,Chongqing China 400021)

机构地区：[1]枣庄市台儿庄区中医院,山东枣庄277400 [2]重庆市中医院,重庆400021

出　　处：《中医学报》2018年第10期1912-1916,共5页Acta Chinese Medicine

基　　金：山东省自然科学基金项目(ZR2010HM042; ZR2011HM002)

摘　　要：目的:观察四磨饮子对老年2型糖尿病肾病患者血清脑源性生长因子水平的影响。方法:68例老年2型糖尿病肾病患者随机分为观察组和对照组各34例。对照组给予厄贝沙坦片150 mg·d-1,口服,每日1次;观察组在对照组治疗基础上给予四磨饮子,每日1剂。两组患者均连续治疗4个月。治疗结束后,比较两组患者临床疗效、认知功能、血清脑源性生长因子、同型半胱氨酸、尿α-1微球蛋白、肾功能以及不良反应发生情况。结果:治疗后,对照组有效率为67. 65%,观察组有效率为88. 24%,两组比较,差异有统计学意义(P <0. 05)。与治疗前比较,两组认知功能以及血清脑源性生长因子水平均升高(P <0. 05);与对照组比较,观察组认知功能以及血清脑源性生长因子水平较高(P <0. 05)。与治疗前比较,两组同型半胱氨酸与尿α-1微球蛋白水平降低(P <0. 05);与对照组比较,观察组同型半胱氨酸与尿α-1微球蛋白水平较低(P <0. 05)。与治疗前比较,两组血清肌酐、尿素氮、血尿酸水平下降,内生肌酐清除率水平升高(P <0. 05);与对照组比较,观察组血清肌酐、尿素氮、血尿酸水平较低,内生肌酐清除率水平较高,差异具有统计学意义(P <0. 05)。两组不良反应发生情况比较,差异无统计学意义(P> 0. 05)。结论:四磨饮子治疗老年2型糖尿病肾病患者疗效显著,可提高血清脑源性生长因子水平,改善认知功能,缓解肾脏损伤。Objective： To observe the effect of Si Mo Yin Zi on serum brain-derived growth factor levels in elderly patients with type2 diabetic nephropathy. Methods： 68 elderly patients with type 2 diabetic nephropathy were randomly divided into observation group and control group. The control group was given irbesartan tablets,with 150 mg·d-1,taken orally once a day; the observation group was given Si Mo Yin Zi in addition to that of the control group,with one dose per day. Both groups of patients were treated continuously for 4 months. After treatment,the clinical efficacy,cognitive function,serum brain-derived growth factor,homocysteine,urinary α-1 microglobulin,renal function and adverse reactions were compared between the two groups. Results： After treatment,the effective rate of the control group was 67. 65%,and the effective rate of the observation group was 88. 24%. The difference was statistically significant（ P〈0. 05）. Compared with that before treatment,the cognitive function and serum brain-derived growth factor levels were significantly increased in the two groups（ P〈0. 05）. Compared with that of the control group,the cognitive function and serum brain-derived growth factor levels were significantly higher in the observation group（ P〈0. 05）. Compared with that before treatment,the levels of homocysteine and urinary α-1 microglobulin were significantly decreased in the two groups（ P〈0. 05）. Compared with that of the control group,the levels of homocysteine and urinary α-1 microglobulin in the observation group were significantly lower（ P〈0. 05）. Compared with that before treatment,serum creatinine,urea nitrogen,and blood uric acid levels significantly decreased,and endogenous creatinine clearance significantly increased（ P〈0. 05）. Compared with that of the control group,serum creatinine,urea nitrogen,and blood uric acid levels were significantly lower in the observation group and the level of endogenous creatinine clearance was significantly higher（ P〈0. 05）. T

关 键 词：四磨饮子 老年2型糖尿病肾病 血清脑源性生长因子 认知功能 同型半胱氨酸 尿α-1微球蛋白 肾功能 厄贝沙坦片 中西医结合 

分 类 号：R259.872[医药卫生—中西医结合]