5α-氨基酮戊酸联合重组人干扰素α-2b凝胶治疗女性尖锐湿疣合并宫颈高危HPV感染  

5α-aminolevulinic acid photodynamic and recombinant interferon α-2b gel therapy for condyloma acuminatum and cervical high risk human papilloma virus infection of female patients

作　　者：马红[1] 许辉[1] 顾文涛[1] 李遇梅[1] MA Hong;XU Hui;GU Wentao;LI Yumei(The Affiliated Hospital of Jiangsu University,Zhengjiang,Jiangsu 212001,China)

机构地区：[1]江苏大学附属医院,江苏镇江212001

出　　处：《中国热带医学》2018年第11期1079-1082,共4页China Tropical Medicine

基　　金：国家自然科学基金(No.81573053);江苏省第四期"333工程"(No.BRA2015196);江苏省妇幼健康科研项目(No.F201717);镇江市第七批科技计划(SS2015024);镇江市社会发展项目(No.SH2017005)

摘　　要：目的观察5α-氨基酮戊酸光动力(5α-aminolevulinic acid photodynamic therapy, ALA-PDT)联合重组人干扰素α-2b凝胶疗法对女性尖锐湿疣(condyloma acuminatum, CA)合并宫颈高危人乳头瘤病毒(human papilloma virus,HPV)感染的临床疗效。方法选择2015—2017年江苏大学附属医院皮肤科门诊诊治的女性尖锐湿疣合并宫颈高危HPV感染的患者60例,采用随机数字法将患者平均分为三组,其中光动力组微波术清除疣体后采用ALA-PDT治疗,干扰素组微波术后采用重组人干扰素α-2b凝胶治疗,联合组采用ALA-PDT联合重组人干扰素α-2b凝胶治疗。结果随访6个月,低危型HPV感染治疗效果,即疣体消失,无新疣体出现:联合组(95.0%)高于光动力组(80.0%)及干扰素组(65.0%),差异有统计学意义(P<0.05)。宫颈高危型HPV感染治疗效果:高危型HPV感染转阴率联合组(95.0%)高于光动力组(70.0%)及干扰素组(55.0%),差异有统计学意义(P<0.05)。三组治疗期间均未出现严重不良反应,所有患者均顺利完成治疗及随访过程。结论微波术清除疣体后,使用光动力联合干扰素凝胶疗法治疗女性尖锐湿疣合并宫颈高危HPV感染,疗效好以及复发率低。Objective In order to observe the clinical efficacy and recurrence of 5-aminolevulinic acid photodynamic therapy（ALA-PDT）and recombinant interferonα-2b gel to treat condyloma acuminatum（CA）and cervicalhigh risk human papilloma virus（HR-HPV）infection in female patients.Methods From 2015 to 2017,60 patients of The Affiliated Hospital of Jiangsu University who were diagnosed as condyloma acuminatum with cervical HR-HPV infection were selected and were randomly divided into 3 groups.The patients of the PDT group were applied topically ALA-PDT after microwave surgery,patients of interferon group were applied topically interferonα-2b gel,the combined group were treated with ALA-PDT and interferonα-2b gel.The clinical efficacy and the change of high-risk HPV test results were observed and compared before and after the treatment for 6 months.Results At 6 months of follow-up,the therapeutic effect of low-risk HPV infection,the verruca disappeared without new warts：the combined group（95.0%）was higher than the PDT group（80.0%）and interferon group（65.0%）,and the difference was statistically significant（P〈0.05）.The therapeutic effect of cervical high-risk HPV infection：the clearance rate of combined group of high-risk HPV infection（95.0%）was higher than that of the PDT group（70.0%）and interferon group（55.0%）,and the difference was statistically significant（P〈0.05）.None of the three groups had serious adverse reactions during the treatment,and all patients successfully completed the treatment and follow-up process.Conclusion Compared with conventional therapies,ALA-PDT and interferonα-2b gel treatment has clinical advantages in clearing condyloma acuminatum with HR-HPV latent infection.

关 键 词：尖锐湿疣 人乳头瘤病毒 光动力 重组人干扰素Α-2B凝胶 

分 类 号：R512.99[医药卫生—内科学]