中国大学生人乳头瘤病毒疫苗知晓率与接受率的Meta分析  

Meta-analysis of awareness rates and acceptance rates of HPV vaccine among Chinese college students

作　　者：郝艳会[1] 石雷[1] HAO Yanhui;SHI lei(Liaoyang Municipal Center for Disease Control and Prevention,Liaoyang,Liaoning 111000,China)

机构地区：[1]辽阳市疾病预防控制中心,辽宁辽阳111000

出　　处：《中国热带医学》2018年第11期1106-1110,共5页China Tropical Medicine

摘　　要：目的评价人乳头瘤病毒(HPV)疫苗在中国大学生人群中的知晓和接受程度。方法检索中国生物医学文献数据库、中国期刊全文数据库、维普数据库和万方全文数据库、PubMed、Embase、Web of Science和Cochrane协作网图书馆数据库,收集2006—2017年公开发表的关于中国大学生对HPV疫苗认知的相关文献,采用AHRQ横断面研究评价量表进行文献质量的评价,对符合纳入标准的文献提取数据纳入分析。运用R-3.5.0统计分析软件的Meta分析方法对效应量进行合并。通过亚组分析和敏感性分析探索异质性来源,采用Egger法评价纳入文献的发表偏倚。结果共15篇文献纳入研究,中国大学生HPV疫苗合并知晓率为18.47%(95%CI:14.23%～22.71%);HPV疫苗合并接受率为71.84%(95%CI:68.03%～75.65%)、中、高质量文献组合并知晓率分别为19.16%、7.74%,医学专业和非医学专业组合并知晓率分别为39.79%、7.7%,亚组间差异有统计学意义。纳入文献的异质性较大,I^2值分别为98.5%和95.3%,通过亚组分析和敏感性分析I^2值并无明显下降,故不能确定异质性的来源。Egger法检验发表偏倚,P值分别为0.13和0.49,尚不能认为纳入文献存在发表偏倚。结论中国大学HPV疫苗的知晓率较低,但疫苗的接受率较高,不同专业和不同文献质量间知晓率有一定差异。Objective To investigate the awareness rates and acceptance rates of human papillomavirus（HPV）vaccine among Chinese college students.Methods Chinese Biomedical Literature Database,Chinese Journal Full-text Database,VIP Database,Wanfang Full-text Database,PubMed,Embase,Web of Science,and Cochrane Collaboration Network Library Database were searched,and the relevant literature on the recognition of HPV vaccines among university students in China published from 2006 to 2017 was collected.The literature quality was evaluated by using AHRQ cross-sectional study evaluation scale.The extracted data of the literature that met the inclusion criteria was included in the analysis.The metaanalysis method was used to combine the effects through the R-3.5.0 statistical analysis software.The source of heterogeneity was explored through the subgroup analysis and sensitivity analysis.The Egger method was used to evaluate the publication biases of the included literature.Results A total of 15 articles were included in the study.The awareness rate of HPV vaccine in Chinese college students was 18.47%（95%CI：14.23%-22.71%）;the acceptance rate of HPV vaccine was 71.84%（95%CI：68.03%-75.65%）.The awareness rates of medium and high quality literature groups were 19.16% and 7.74% respectively,the awareness rates of medical and non-medical professional groups were 39.79% and 7.7%respectively,and the difference between the subgroups was statistically significant.The heterogeneity of the included literature was relatively large,with of 98.5% and 95.3%,respectively.The I^2 values of subgroup analysis and sensitivity analysis did not decrease significantly,so the source of heterogeneity could not be determined.The Egger method that was used to evaluate the publication biases showed that the P values were 0.13 and 0.49,respectively,and the published literature was not considered of being biased.Conclusion s The awareness rate of HPV vaccine in Chinese college students is low,but the vaccine acceptance rate is relatively high.Ther

关 键 词：HPV疫苗 知晓率 接受率 META-分析 

分 类 号：R711.74[医药卫生—妇产科学]