氨基末端B型脑钠肽前体对急性肺栓塞危险程度及预后的评估价值  

Evaluation Value of Risk and Prognosis of N-terminalof Risk and Prognosis Type B pro Brain Natriuretic Peptide for Acute Pulmonary Embolism

作　　者：黄猛[1] HUANG Meng(Department of respiratory medicine,Gaozhou people＇s Hospital,Guangdong Province,52520)

机构地区：[1]广东省高州市人民医院呼吸内科,525200

出　　处：《岭南急诊医学杂志》2018年第5期425-427,共3页Lingnan Journal of Emergency Medicine

摘　　要：目的:探讨氨基末端B型脑钠肽前体(NT-proBNP)对急性肺栓塞患者危险程度及预后的评估作用。方法:选择我院2011年4月至2015年10月收治的急性肺栓塞患者93例为研究对象,根据危险程度分组,高危组21例,中危组38例,低危组34例,分别对三组患者临床指标进行对比;根据是否存在右心功能不全分为右心功能正常组与右心功能不全组,对两组NT-proBNP水平进行对比;根据患者预后结局分为预后不良组与预后良好组,对NT-proBNP水平进行对比分析。结果:高危组的NT-proBNP水平、心率、D-二聚体(D-D)、肌钙蛋白I(cTn I)及右心功能不全比例均明显高于中危组与低危组(P<0.05);右心功能不全组的NT-proBNP水平显著高于右心功能正常组(P<0.05);预后不良组的NT-proBNP水平明显较预后良好组高(P<0.05)。结论:NT-proBNP水平可对急性肺栓塞危险程度进行评估,也能作为预后右心功能及预后的敏感性指标,值得临床推广。Objective ： To investigate the evaluation role of risk and prognosis of N-terminal type B pro brain natriuretic peptide （NT-proBNP） in patients with acute pulmonary embolism. Methods：93 cases of patients with acute pulmonary embolism treated in our hospital from April, 2011 to October, 2015 were selected as the research objects, and were grouped according to the risk level. There were 21 cases of high-risk group, 38 cases of moderate risk group and 34 cases of low risk group. The clinical indexes of the three groups of patients were compared. Patients were divided into the right heart function normal group and the right heart insufficiency group according to whether existence of right cardiac insufficiency. The NT-proBNP levels of two groups were compared. The patients were divided into poor prognosis group and good prognosis group according to the outcome of the patient, the level of NT-proBNP was compared and analyzed. Results. The NT-proBNP level, heart rate, D- two dimer （D-D）, troponin I （cTn I） and right ventricular dysfunction ratio in the high risk group were significantly higher than those in the middle risk group and the low risk group （P〈 0.05）. The NT-proBNP level in the right ventricular dysfunction group was significantly higher than that in the right heart function group （P〈0.05）. The NT-proBNP level in the poor prognosis group was significantly higher than that in the good prognosis group （P〈0.05）. Conclusion： The NT-proBNP level can be used to assess the risk of acute pulmonary embolism, and can also be used as a sensitive index for prognosis of right heart function and prognosis, thus it is worthy to be promoted in the clinical.

关 键 词：氨基末端B型脑钠肽前体 急性肺栓塞 预后 危险程度 

分 类 号：R563.5[医药卫生—呼吸系统]