假体周围骨溶解机制及相关信号通路的最新研究进展  

Latest research progress of periprosthetic osteolysis mechanism and related signaling pathway

作　　者：刘慧敏[1] 王亚飞 廖云健 廉永云[1] 董锋[1] 逯代锋[1] 李红喜[1] 张志涛[1] Liu Huimin;Wang Yafei;Liao Yunjian;Lian Yongyun;Dong Feng;Lu Daifeng;Li Hongxi;Zhang Zhitao(Department of Orthopedics,Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第四医院骨科,150001

出　　处：《国际外科学杂志》2018年第11期773-779,共7页International Journal of Surgery

基　　金：哈尔滨医科大学第四临床医学院院长基金（HYDSYYZ201504）

摘　　要：人工关节置换术是治疗包括髋、膝关节等严重关节终末期疾病的重要手段，获得了令人满意的临床疗效，但术后磨损颗粒介导的假体周围骨溶解（PPO）却制约了人工关节的远期疗效。磨损颗粒通过刺激假体周围细胞，导致细胞因子及炎性因子表达增多，激活不同的信号通路，促使成骨细胞介导的骨形成和破骨细胞介导的骨吸收失衡以致局部骨量丢失，最终发生骨溶解和无菌性松动。该文就近年来磨损颗粒激活的不同信号通路作一综述，以期探索PPO的发病机制及为其的防治开辟新的途径。Artificial joint replacement is an important means for the treatment of severe joint end-stage diseases such as hip and knee joint, which has obtained satisfactory clinical efficacy, but the postoperative periprosthetic osteolysis （PPO）, which is mediated by wear particles, restricts the long-term effect of artificial joints. It is found that wear particles increase the expression of eytokines and inflammatory factors by stimulating the cells around the prosthesis, activate different signaling pathways, promote the imbalance between bone formation mediated by local osteoblasts and bone resorption mediated by osteoclast so as to lose of the local bone mass, and eventually produce osteolysis and aseptic loosening. This article reviews the different signal pathways activated by wear particles in recent years, in order to explore the pathogenesis of PPO and to open up new avenues for its prevention and treatment.

关 键 词：骨质溶解 信号通路 机制 

分 类 号：R687.4[医药卫生—骨科学]