原发性胆汁性胆管炎患者血清游离TAM受体家族分子的水平及临床意义  

Levels of TAM receptor family in serum of patients with primary biliary cholangitis and their clinical significance

作　　者：梁艳[1] 秦保东[2] 史虹[1] 张振成 仲人前[1] 杨再兴 LIANG Yah;QIN Baodong;SHI Hong;ZHANG Zhencheng;ZHONG Renqian;YANG Zaixing(Department of Laboratory Diagnostics;Department of Oncology,Changzheng Hospital,Shanghai 200003;Department of Laboratory Medicine,Huangyan Hospital of Wenzhou Medical University,Taizhou First People＇s Hospital,Taizhou 318020,Zhejiang,China)

机构地区：[1]上海长征医院实验诊断科,上海200003 [2]上海长征医院肿瘤科,上海200003 [3]温州医科大学附属黄岩医院台州市第一人民医院检验科,浙江台州318020

出　　处：《临床检验杂志》2018年第10期729-731,共3页Chinese Journal of Clinical Laboratory Science

基　　金：国家自然科学基金(81571591;81671594)

摘　　要：目的探讨血清游离TAM受体家族分子在原发性胆汁性胆管炎(PBC)中的水平变化及其临床意义。方法收集PBC患者64例和健康人对照57例。用ELISA法检测血清Gas6、蛋白S、s Tyro-3、s Axl和s Mer的水平,在PBC患者和健康人对照间进行结果比较,在PBC中分析这些分子与肝功能生化指标的相关性。结果 PBC患者血清蛋白S水平明显低于健康人对照(P<0.001),而s Mer和s Tyro-3水平明显高于健康人对照(P<0.001),Gas6和s Axl水平在两组之间差异无统计学意义。在PBC患者中,血清s Mer和s Tyro-3与碱性磷酸酶(ALP)、γ-谷氨酰基转移酶(GGT)、总胆汁酸(TBA)之间呈正相关,相关性有统计学意义(P<0.05),但Gas6、蛋白S和s Axl与肝功能生化指标之间无相关性。结论血清蛋白S、s Mer和s Tyro-3水平在PBC中明显改变,s Mer和s Tyro-3可能反映PBC病情,而血清Gas6和s Axl在PBC中无明显改变。Objective To explore the changes of the levels of TAM receptor family and their clinical significances in serum of primary biliary cholangitis（ PBC） patients. Methods A total of 64 PBC patients and 57 healthy controls were recruited. Enzyme-linked immunosorbent assay（ ELISA） was used to detect the levels of serum Gas6,protein S,s Tyro-3,s Axl and s Mer. The results between PBC patients and healthy controls were compared. The correlations between the levels of these molecules and liver biochemical indices in PBC patients were analyzed. Results The level of protein S in serum of PBC patients was significantly lower than that of healthy controls（ P〈0.001）,while s Mer and s Tyro-3 were higher than those of healthy controls（ P〈0.001）. There was no significant difference for the levels of Gas6 and s Axl between the two groups. In the patients with PBC,the levels of s Mer and s Tyro-3 were significantly positively correlated with alkaline phosphatase（ ALP）,γ-glutamyl transferase（ GGT） and total bile acid（ TBA） in serum（ P〈0.05）,while Gas6,protein S and s Axl were not correlated with the biochemical indices of liver. Conclusions The levels of protein S,s Mer and s Tyro-3 could be significantly changed in serum of PBC patients. s Mer and s Tyro-3 may reflect the disease status of PBC patients.However,the levels of Gas6 and s Axl are not changed significantly in those with PBC.

关 键 词：原发性胆汁性胆管炎 TAM受体 

分 类 号：R446.6[医药卫生—诊断学]