多囊卵巢综合征患者血清miR-21表达与肥胖和糖脂代谢的关系  

The expression of serum miR-21 of women with polycystic ovary syndrome and the relationship betwwn miR-21 expression and obesity or metabolism of glucose and lipid

作　　者：白爱红[1] 滕少侠[1] 谢文燕[1] 李荣香[1] 胥博 付秀虹[1] BAI Aihong;TENG Shaoxia;XIE Wenyan;LI Rongxiang;XU Bo;FU Xiuhong(Luohe Central Hospital,Henan Province,46200)

机构地区：[1]河南省漯河市中心医院,462000

出　　处：《中国计划生育学杂志》2018年第11期1094-1097,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨多囊卵巢综合征患者血清miR-21表达特点及与肥胖、糖脂代谢关系。方法:连续性选取2016年2月-2017年12月本院生殖医学与遗传中心就医的PCOS患者96例为研究对象(观察组),并选择60例基础体温双相的不孕症患者为对照组。采用实时定量PCR技术检测两组血清miR-21表达,以BMI≥25kg/m2为肥胖,将PCOS患者分为PCOS合并肥胖组、PCOS正常体重组;依据血脂血糖水平将患者分为PCOS合并糖脂代谢异常组、PCOS糖脂代谢正常组,分析各组血清miR-21的表达差异,Pearson相关性分析miR-21与肥胖、糖脂代谢异常的相关性。结果:血清miR-21观察组(2.71±0.69)高于对照组(1.10±0.26),PCOS合并肥胖患者(2.91±0.82)高于PCOS正常体重患者(1.80±0.36),PCOS合并糖脂代谢异常组患者(2.81±0.72)高于PCOS糖脂代谢正常组(1.50±0.16)(均P<0.05);观察组miR-21与LDL-C、HOMA-IR、BMI均呈正相关(r=0.430、0.516、0.356,P<0.05),与对照组无相关性。结论:PCOS患者血清miR-21表达明显上调,且与PCOS患者肥胖程度和糖脂代谢异常有关。Objective To explore the relationship between serum miR 21 expression of women with polycystic ovary syndrome （PCOS） and their obesity or metabolism of glucose and lipid. Methods： 96 women with PCOS （in observation group） were treated in Luohe central hospital of Henan province from February 2016 to December 2017 were selected into the data. At the same time, another 60 infertility women with basal body temperature were selected into control group. Serum miR 21 expressions of women in the two groups were detected by RT PCR. The obesity of women diagnosed by BMI 〉 25 kg/m 2, and 96 women with PCOS were also divided into PCOS with obesity group and PCOS with normal weight group. The expressions of serum miR 21 of women in different group were analyzed and compared. Pearson correlation analysis had been used to find the correlation between miR 21 and obesity or abnormal glucose and lipid metabolism. Results： The serum miR 21 expressions of women in observation group （2.71±0.69） was significant higher than that （1.10±0.26） of women in control group （ P 〈0.05）. The serum miR 21 expressions of obesity women with PCOS （2.91±0.82） was significant higher than that （1.80±0.36） of normal weight women with PCOS （ P 〈 0.05）. The serum miR 21 of expressions of abnormal glucose and lipid metabolism women with PCOS （ 2.81 ±0.72） was significant higher than that （1.50±0.16） of normal glucose metabolism women with PCOS （ P 〈 0.05 ）. There was a positive correlation between miR 21 and LDL C, HOMA IR or BMI of women in observation group （ r=0.430, 0.516, 0.356, P 〈0.05）, but there was no correlation between miR 21 and LDL C, HOMA IR or BMI of women in control group. Conclusion： The expression of miR 21 is up regulated of women with PCOS, and it is associated with obesity and abnormal glucose and lipid metabolism of women with PCOS.

关 键 词：多囊卵巢综合征 血清miR-21 肥胖 糖脂代谢 

分 类 号：R711.75[医药卫生—妇产科学]