男性不同类型染色体多态性对常规体外受精治疗结局的影响  

The effect of different type chromosome polymorphismfrom of male on outcomes of conventional IVF

作　　者：乜照燕[1] 张娜[1] 甄秀丽[1] 赵素英[1] 张轶[1] 吴海峰[2] NIE Zhaoyan;ZHANG Na;ZHEN Xiuli;ZHAO Suying;ZHANG Yi;WU Haifeng(The Fourth Affiliated Hospital of Hebei Medical University,Shijiazhuang,Hebei Province,050011;Hebei thoracic hospital)

机构地区：[1]河北医科大学第四医院,石家庄050011 [2]河北省胸科医院

出　　处：《中国计划生育学杂志》2018年第11期1123-1125,1140,共4页Chinese Journal of Family Planning

基　　金：河北省医学科学研究重点课题计划(资助号:1020140140)

摘　　要：目的:探讨男性不同类型染色体多态性对常规体外受精(IVF)治疗结局的影响。方法:回顾性分析2014年6月-2016年6月在本院接受常规IVF行染色体核型分析的患者,根据男性染色体多态性分为4组,其中D/G随体增加者为A组21例,次溢痕增加(包括1号、9号、16号染色体)为B组20例,9号染色体臂间倒位为C组17例,Y染色体变异(包括大Y和小Y)为D组20例,正常者为对照组120例。对各组精液参数、胚胎发育以及临床妊娠结局进行比较。结果:5组精液量、精子浓度、前向精子百分比、存活率和精子正常形态比较差异无统计学意义(P>0.05),正常受精率、总受精率、优胚率、植入率、床妊娠率以及早期流产率差异无统计学意义(P>0.05)。结论:男性染色体不同类型的多态性对于实施常规IVF-ET治疗结局无明显影响。Objective To investigate the effects of different types of chromosomal polymorphism of male on outcomes of conventional in vitro fertilization （IVF）. Methods： A retrospective analysis was performed about patients undergone routine IVF AND karyotype analysis in the fourth hospital of Hebei medical university between June 2014 to June 2016. According to the chromosome polymorphism of male, the patients were divided into four groups： patients with D/G satellite increased in group A （n=21）, patients with secondary constriction increases, which included 1, 9, and 16 chromosomes in group B （n=20）, patients with pericentric inversion of chromosome 9 in group C （n=17）, patients with big or small Y chromosome in group D （n=20）, and patients with normal karyotype in group E （n=120）. The semen parameters, situation of embryonic development, and pregnancy outcomes were compared among the groups. Results： There were no statistical significant different in semen volume, sperm concentration, percentage of sperm moving forward, rate of sperm viability, and rate of sperm normal morphology among the five groups （ P 〉 0.05 ）. And There were also no statistically significant different in normal fertilization rate, total fertilization rate, good embryo rate, embryo implantation rate, clinical pregnancy rate, and early abortion rate among the five groups （ P 〉 0.05 ）. Conclusion： The different types of male chromosome polymorphism has no any significant effect on outcomes of routine IVF.

关 键 词：染色体多态性 体外受精 精液质量 胚胎发育 妊娠结局 

分 类 号：R714.8[医药卫生—妇产科学]