糖化血红蛋白、C肽与2型糖尿病周围神经病变的相关性分析  

Correlation analysis between glycosylated hemoglobin, C-peptide and peripheral neuropathy in type 2 diabetes

作　　者：万芳[1] WAN Fang(Department of Endocrinology,the First People＇s Hospital of Jiujiang City in Jiangxi Province,Jiujiang 332000,China)

机构地区：[1]江西省九江市第一人民医院内分泌科,江西九江332000

出　　处：《中国现代医生》2018年第29期27-29,共3页China Modern Doctor

基　　金：江西省卫生计生委科技计划(20177080)

摘　　要：目的探讨糖化血红蛋白(HbA1c)、C肽(C-P)与2型糖尿病周围神经病变(DPN)的关系。方法选择我院2017年1月~2018年3月期间的80例2型糖尿病患者作为研究对象,根据是否合并DPN分为DPN组(42例)和NDPN组(38例),比较两组临床资料和糖化血红蛋白、C肽等指标,采用单因素和Logistic回归分析进行相关性分析。结果 DPN组的Hb A1c、空腹C-P浓度和餐后2 h C-P水平(2 h C-P)分别为(8.52±1.41)%、(1.44±0.51)ng/mL和(2.37±0.42)ng/mL,而NDPN组为(6.58±1.04)%、(1.62±0.63)ng/mL和(2.84±0.57)ng/mL,两组HbA1c和2 h C-P比较差异均有统计学意义(P<0.05),而空腹C-P水平差异无统计学意义(P>0.05)。Logistic回归分析显示,病程、HbA1c和2 h C-P均是DPN发生的相关危险因素(P<0.05)。结论 2型糖尿病周围神经病变与糖化血红蛋白和C肽密切相关,应在糖尿病早期对相关危险因素进行干预和预防,以降低糖尿病周围神经病变的发生。Objective To investigate the relationship between glycated hemoglobin （HbA1c）, C-peptide （C-P） and type2 diabetic peripheral neuropathy（DPN）. Methods 80 patients with type 2 diabetes mellitus from January 2017 to March2018 were enrolled in our study. According to whether the combination of DPN, the paients were divided into DPNgroup（n=42） and NDPN group（n=38）. The clinical data, the indicators of glycosylated hemoglobin and C-peptide betweenthe two groups were compared. And the correlation analysis wsa analyzed by single factor and logistic regression analysis.Results The HbA1c, fasting C-P concentration and postprandial 2 h C-P level （2 h C-P） in the DPN group were（8.52±1.41）%,（1.44±0.51） ng/mL and （2.37±0.42） ng/mL, respectively, while HbA1c, fasting C-P concentration andpostprandial 2 h C-P level （2 h C-P） in the NDPN group were（6.58±1.04）%, （1.62±0.63） ng/mL and （2.84±0.57） ng/mL.The difference of HbA1c and 2 h C-P between the two groups were statistically significant（P〈0.05）, while fasting C-Phad no significant difference（P〉0.05）. Logistic regression analysis showed that duration of disease, HbA1c and 2 h C-Pwere risk factors for the occurrence of DPN（P〈0.05）. Conclusion Type 2 diabetic peripheral neuropathy is closelyrelated to glycosylated hemoglobin and C-peptide. Intervention and prevention of relevant risk factors should be performed in the early stage of diabetes to reduce the occurrence of diabetic peripheral neuropathy.

关 键 词：2型糖尿病 糖化血红蛋白 C肽 相关性 糖尿病周围神经病变 

分 类 号：R587.2[医药卫生—内分泌]