风湿宁胶囊大孔树脂纯化工艺研究  

Macroporous Resin Purification Technology of Fengshining Capsule

作　　者：王鹏飞 刘培 叶花 王科 王嘉琛 段秀俊 WANG Peng-fei;LIU Pei;YE Hua;WANG Ke;WANG Jia-chen;DUAN Xiu-jun(Shanxi College of Traditional Chinese Medicine,Yuci 030600,China)

机构地区：[1]山西中医药大学,山西榆次030600

出　　处：《中国现代中药》2018年第10期1278-1281,共4页Modern Chinese Medicine

基　　金：国家科技重大专项重大新药创制项目(2010ZX09102-210);山西省科技产业化环境建设项目(2012061014-3)

摘　　要：目的:研究风湿宁胶囊的大孔树脂纯化工艺。方法:以青藤碱为评价指标,采用单因素实验法考察大孔树脂纯化的工艺参数。结果:D-101型大孔树脂吸附能力最强,上样液浓度为1∶1,上样流速为1 BV·h^(-1),洗脱溶剂为50%的乙醇,洗脱流速为2 BV·h^(-1),洗脱量为10 BV;树脂至少可重复使用5次。结论:对筛选的工艺条件进行验证,青藤碱回收率可达98%,且基本稳定,大孔树脂可用于风湿宁胶囊的纯化。Objective： To study the purification technology of Fengshining Capsule. Methods： With sinomenine as evaluation index, to study technological parameters of maeroporous resin purification by single factor experiment method. Results： D-101 was chosen to purify, the concentration of loading sample was 1：1, the flowing rate was 1 BV ·h-1; and the eluent solvent was 50% ethanol, the flowing rate was 2 BV · h-l , the eluent amount was 10 BV. The macroporous res- in can be used at least 5 times. Conclusion： The screening conditions was verified, sinomenine recovery rate can reach 98%, and basically stable, macroporous resin can be used for purification of Fengshining Capsule.

关 键 词：风湿宁胶囊 青藤碱 大孔树脂 纯化工艺 

分 类 号：R283.6[医药卫生—中药学]