固元益血汤联合HAAG方案治疗进展期急性髓系白血病儿童临床研究  

Effect of Guyuan Yishen Decoction Combined with HAAG Regimen on Children with Advanced Myeloid Leukemia

作　　者：王晓利[1] 张辉果[1] Wang Xiaoli;Zhang Huiguo(Department of Pediatrics,Henan Traditional Chinese Medicine Hospital,Zhengzhou 450002,China)

机构地区：[1]河南省中医院儿科,河南郑州450002

出　　处：《亚太传统医药》2018年第11期158-160,共3页Asia-Pacific Traditional Medicine

摘　　要：目的:探究固元益血汤联合HAAG方案治疗进展期急性髓系白血病(AML)患儿的临床疗效。方法:选取42例AML患儿,按照随机数字表法分为对照组与观察组各21例。对照组患儿给予HAAG方案(重组人粒细胞集落刺激因子(G-CSF)、柔比星(Acla)、阿糖胞苷(Ara-C)和三尖杉酯碱(HHT))治疗,观察组患儿在对照组治疗基础上给予中药固元益血汤治疗,比较两组患儿治疗前后血常规检查结果、患儿治疗后不良反应、缓解率以及治疗前后的卡氏评分。结果:两组患儿治疗后体内血红蛋白、血小板和白细胞含量均有所上升,观察组升高程度更明显,两组患儿治疗前血红蛋白、血小板和白细胞含量比较,差异均无统计学意义(P>0.05),治疗后血红蛋白和白细胞含量比较,差异有统计学意义(P<0.05),两组患儿治疗后血小板含量比较,差异无统计学意义(P>0.05)。观察组患儿的较严重并发症如感染、恶心等不良反应发生率明显低于对照组,差异均具有统计学意义(P<0.05)。观察组患者的缓解率为85.7%,高于对照组的66.7%,差异具有统计学意义(P<0.05)。观察组治疗后卡氏评分升高程度较对照组明显,观察组治疗前后卡氏评分比较,差异具有统计学意义(P<0.05)。结论:固元益血汤联合HAAG方案治疗儿童进展期急性髓系白血病儿童效果较好,能够明显改善患儿的生存质量,值得临床推广应用。Objective：To study the clinical effect of Guyuan Yixue Decoction combined with HAAG regimen in the treatment of acute myeloid leukemia（AML）.Methods：A total of 42 AML children who were treated in our hospital from January 2012 to November 2015 were randomly divided into control group and observation group according to the random number table method.The patients in the control group were treated with HAAG regimen（recombinant human granulocyte colony-stimulating factor（G-CSF）,ibuprofen（Acla）,cytarabine（Ara-C）and homoharringtonine（HHT）The observation group was given the traditional Chinese medicine Guyuan Yishen Decoction on the basis of the control group.The results of blood routine examination and treatment,the adverse reaction rate,the remission rate and the card score before and after treatment were compared between the two groups before and after treatment.Results：The content of hemoglobin,platelet and leukocyte in the two groups increased after treatment,and the level of the observation group increased more obviously.There was no significant difference in the content of hemoglobin,platelet and leukocyte between the two groups before treatment（P〈0.05）.There was no significant difference in platelet content between the two groups after treatment（P〈0.05）.There was no significant difference in hemoglobin,platelet and leukocyte contents between the observation group and the control group before treatment（P〈0.05）.After treatment,the hemoglobin and leukocyte contents in the observation group were significantly improved compared with those in the control group,and there was significant difference between the two groups（P〈0.05）.The difference was not statistically significant（P〈0.05）.The incidence of infection,fever,vomiting ver,vomiting and nausea in the observation group was lower than that in the control group,and the difference between the two groups was statistically significant（P〈0.05）.After treatment,the Karl＇s score of the two groups increased sig

关 键 词：进展期急性髓系白血病 HAAG方案 固元益血汤 儿童 

分 类 号：R246.4[医药卫生—针灸推拿学]